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    TLG1 Tlg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852079, updated on 18-Sep-2024

    Summary

    Official Symbol
    TLG1
    Official Full Name
    Tlg1p
    Primary source
    SGD:S000002876
    Locus tag
    YDR468C
    See related
    AllianceGenome:SGD:S000002876; FungiDB:YDR468C; VEuPathDB:YDR468C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity. Involved in endocytosis and vesicle fusion. Located in endosome and trans-Golgi network. Part of SNARE complex. Orthologous to human STX10 (syntaxin 10) and STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See TLG1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1398026..1398700, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein-arginine N5-methyltransferase Neighboring gene protein kinase PKH3 Neighboring gene Sdc1p Neighboring gene Ugo1p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Tlg1p
    NP_010756.3
    • Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1398026..1398700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180776.3NP_010756.3  TPA: Tlg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010756.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT92, Q03322
      UniProtKB/TrEMBL
      A6ZZ58, B3LFJ7, B5VGZ7, C7GKQ9, C8Z627, G2WBJ8, N1P7K3
      Conserved Domains (2) summary
      cd15851
      Location:135200
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
      cd21444
      Location:692
      SNARE_NTD_Tlg1p-like; N-terminal domain of t-SNARE affecting a late Golgi compartment protein 1 and similar proteins