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    UGO1 Ugo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852081, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UGO1
    Official Full Name
    Ugo1p
    Primary source
    SGD:S000002878
    Locus tag
    YDR470C
    See related
    AllianceGenome:SGD:S000002878; FungiDB:YDR470C; VEuPathDB:YDR470C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable thiamine transmembrane transporter activity. Involved in mitochondrial fusion. Is integral component of mitochondrial outer membrane. Used to study Leigh disease. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UGO1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1399706..1401214, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tlg1p Neighboring gene Sdc1p Neighboring gene ribosomal 60S subunit protein L27B Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial outer and inner membrane fusion requires a modified carrier protein. Hoppins S, et al. J Cell Biol, 2009 Feb 23. PMID 19237599, Free PMC Article
    2. Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Coonrod EM, et al. Traffic, 2007 May. PMID 17451553
    3. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. Janer A, et al. EMBO Mol Med, 2016 Sep. PMID 27390132, Free PMC Article
    4. UGO1 encodes an outer membrane protein required for mitochondrial fusion. Sesaki H, et al. J Cell Biol, 2001 Mar 19. PMID 11257114, Free PMC Article
    5. The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. Vögtle FN, et al. J Cell Biol, 2015 Sep 14. PMID 26347140, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reconstituted the import and assembly pathway of Ugo1 in protein-free liposomes, mimicking the outer membrane phospholipid composition, and found a direct dependency of Ugo1 biogenesis on phosphatidic acid.
      Title: The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.
    2. Ugo1 is inserted into the MOM by a novel pathway in which Tom70 and Mim1 contribute to the efficiency and selectivity of the process.
      Title: Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway.
    3. Fzo1 assembles into homo-dimers, depending on Ugo1 and on GTP binding to Fzo1.
      Title: Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion.
    4. Findings demonstrate that Ugo1 plays a unique, postmembrane tethering role in mitochondrial fusion.
      Title: Mitochondrial outer and inner membrane fusion requires a modified carrier protein.
    5. PCD2 was identified as a functional (fusion)domain of Ugo1p thata contains at least one additional transmembrane domain that mediates outer membrame targeting and fusion.
      Title: Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ugo1p
    NP_010758.3
    • Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but likely not a transporter; similar to human SLC25A46 implicated in optic atroprophy spectrum disorder and Leigh syndrome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1399706..1401214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180778.2 → NP_010758.3  TPA: Ugo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010758.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT94, Q03327
      UniProtKB/TrEMBL
      B3LFJ5, C8Z629, N1P7C5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03327.3

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