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    ECT1 ethanolamine-phosphate cytidylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852890, updated on 1-Aug-2024

    Summary

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    Gene symbol
    ECT1
    Gene description
    ethanolamine-phosphate cytidylyltransferase
    Primary source
    FungiDB:YGR007W
    Locus tag
    YGR007W
    See related
    SGD:S000003239; AllianceGenome:SGD:S000003239; VEuPathDB:YGR007W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MUQ1
    Summary
    Enables ethanolamine-phosphate cytidylyltransferase activity. Involved in phosphatidylethanolamine biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ECT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (506969..507940)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor IIF subunit TFG2 Neighboring gene mRNA splicing protein PRP18 Neighboring gene ATPase-stabilizing factor family protein Neighboring gene Sec9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction of a yeast strain with regulatable phospholipid synthesis for analysis of the uptake and metabolism of phosphatidylethanolamine with short acyl chains. Deng L, et al. Biosci Biotechnol Biochem, 2007 Sep. PMID 17827694
    2. Crystallization and preliminary X-ray analysis of CTP:phosphoethanolamine cytidylyltransferase (ECT) from Saccharomyces cerevisiae. Ohtsuka J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Oct 1. PMID 17012796, Free PMC Article
    3. Isolation and characterization of ECT1 gene encoding CTP: phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae. Min-Seok R, et al. J Biochem, 1996 Nov. PMID 8982874
    4. Human CTP:phosphoethanolamine cytidylyltransferase: enzymatic properties and unequal catalytic roles of CTP-binding motifs in two cytidylyltransferase domains. Tian S, et al. Biochem Biophys Res Commun, 2014 Jun 20. PMID 24802409
    5. Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant. Nakashima A, et al. J Biol Chem, 1997 Apr 4. PMID 9083101

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ethanolamine-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethanolamine-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ethanolamine-phosphate cytidylyltransferase
    NP_011521.1
    • Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      506969..507940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181136.1 → NP_011521.1  TPA: ethanolamine-phosphate cytidylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUE4, P33412, Q05725
      UniProtKB/TrEMBL
      A6ZUZ9, B3LIK9, B5VIW8, C7GK77, C8Z8Q1, G2WEA0, N1P9T8
      Conserved Domains (2) summary
      PTZ00308
      Location:9 → 321
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
      cd02174
      Location:6 → 157
      CCT; CTP:phosphocholine cytidylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33412.1

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