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    COX23 Cox23p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856516, updated on 17-May-2024

    Summary

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    Gene symbol
    COX23
    Gene description
    Cox23p
    Primary source
    FungiDB:YHR116W
    Locus tag
    YHR116W
    See related
    SGD:S000001158; AllianceGenome:SGD:S000001158; VEuPathDB:YHR116W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial respiratory chain complex assembly. Located in mitochondrion. Orthologous to human CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COX23 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (341665..342120)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Bzz1p Neighboring gene ubiquitin-conjugating protein DMA1 Neighboring gene protein channel TOM71 Neighboring gene origin recognition complex subunit 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COX23, a homologue of COX17, is required for cytochrome oxidase assembly. Barros MH, et al. J Biol Chem, 2004 Jul 23. PMID 15145942
    2. The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. Murtha K, et al. Curr Genet, 2019 Apr. PMID 30317392, Free PMC Article
    3. Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12. Abe-Kanoh N, et al. Sci Rep, 2019 Jun 20. PMID 31222108, Free PMC Article
    4. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468
    5. A Role for the Respiratory Chain in Regulating Meiosis Initiation in Saccharomyces cerevisiae. Zhao H, et al. Genetics, 2018 Mar. PMID 29301906, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox23p
    NP_011984.1
    • Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      341665..342120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179246.1 → NP_011984.1  TPA: Cox23p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL66, P38824
      UniProtKB/TrEMBL
      A0A6A5PYG7, A6ZT24, B3LSN1, C7GR62, C8Z9Q9, N1P4N8
      Conserved Domains (1) summary
      pfam06747
      Location:104 → 138
      CHCH; CHCH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38824.1

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