ADO1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADO1
Primary source: SGD:S000003866
Locus tag: YJR105W
See related: AllianceGenome:SGD:S000003866; FungiDB:YJR105W; VEuPathDB:YJR105W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables adenosine kinase activity. Involved in purine nucleobase metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (623581..624603)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors identified ADO1 encoding adenosine kinase as one of the factors participating in high S-adenosylmethionine accumulation.
Title: Adenosine kinase-deficient mutant of Saccharomyces cerevisiae accumulates S-adenosylmethionine because of an enhanced methionine biosynthesis pathway.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosine kinase activity	IEA Inferred from Electronic Annotation more info
enables adenosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP salvage	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleobase metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenosine kinase

NP_012639.1

EC 2.7.1.20

Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

623581..624603

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181763.1 → NP_012639.1 TPA: adenosine kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWS4, P47143

UniProtKB/TrEMBL

B3LQI9, C7GMA3, C8ZBQ2, N1P083

Conserved Domains (1) summary

cd01168
Location:5 → 332

adenosine_kinase; Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine ...