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    CPA2 carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853573, updated on 4-Aug-2024

    Summary

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    Gene symbol
    CPA2
    Gene description
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
    Primary source
    FungiDB:YJR109C
    Locus tag
    YJR109C
    See related
    SGD:S000003870; AllianceGenome:SGD:S000003870; VEuPathDB:YJR109C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in arginine biosynthetic process. Part of carbamoyl-phosphate synthase complex. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CPA2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (629585..632941, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Abm1p Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene Pxp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of ATP-grasp residues in the two ATP sites of Saccharomyces cerevisiae carbamoyl phosphate synthetase. Eroglu B, et al. Arch Biochem Biophys, 2002 Nov 1. PMID 12392708
    2. Identification of critical amino acid residues of Saccharomyces cerevisiae carbamoyl-phosphate synthetase: definition of the ATP site involved in carboxy-phosphate formation. Zheng W, et al. Biochim Biophys Acta, 1997 Aug 15. PMID 9300807
    3. Critical roles for arginine 1061/1060 and tyrosine 1057 in Saccharomyces cerevisiae arginine-specific carbamoyl-phosphate synthetase. Lim AL, et al. Arch Biochem Biophys, 1997 Mar 15. PMID 9056267
    4. Yeast carbamyl phosphate synthetase. Structure of the yeast gene and homology to Escherichia coli carbamyl phosphate synthetase. Lusty CJ, et al. J Biol Chem, 1983 Dec 10. PMID 6358221
    5. Cloning of a yeast gene coding for arginine-specific carbamoyl-phosphate synthetase. Lusty CJ, et al. Proc Natl Acad Sci U S A, 1982 Apr. PMID 6285375, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate carbamoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbamoyl-phosphate synthase (ammonia) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dihydroorotase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in citrulline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
    NP_012643.3
    • Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      629585..632941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181767.3 → NP_012643.3  TPA: carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012643.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWS8, P03965
      UniProtKB/TrEMBL
      A6ZQ65, B3LQJ3, B5VLQ3, C7GMA0, C8ZBQ7, G2WHB2, N1P185
      Conserved Domains (1) summary
      TIGR01369
      Location:23 → 1084
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03965.1

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