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    PEX21 Pex21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853154, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX21
    Official Full Name
    Pex21p
    Primary source
    SGD:S000003471
    Locus tag
    YGR239C
    See related
    AllianceGenome:SGD:S000003471; FungiDB:YGR239C; VEuPathDB:YGR239C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of binding activity and protein import into peroxisome matrix. Located in cytosol and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PEX21 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (969187..970053, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kel2p Neighboring gene 6-phosphofructokinase subunit alpha Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying Pex21p as a protein that specifically interacts with yeast seryl-tRNA synthetase. Rocak S, et al. FEMS Microbiol Lett, 2002 Aug 27. PMID 12204379
    2. Peroxin Pex21p interacts with the C-terminal noncatalytic domain of yeast seryl-tRNA synthetase and forms a specific ternary complex with tRNA(Ser). Godinic V, et al. FEBS J, 2007 Jun. PMID 17451428
    3. The proximal region of a noncatalytic eukaryotic seryl-tRNA synthetase extension is required for protein stability in vitro and in vivo. Mocibob M, et al. Arch Biochem Biophys, 2008 Feb 15. PMID 18067851
    4. Pex7p and Pex20p of Neurospora crassa function together in PTS2-dependent protein import into peroxisomes. Sichting M, et al. Mol Biol Cell, 2003 Feb. PMID 12589072, Free PMC Article
    5. Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p. Pan D, et al. Nat Struct Mol Biol, 2013 Aug. PMID 23812376

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pex21p
    NP_011755.3
    • Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      969187..970053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181368.3 → NP_011755.3  TPA: Pex21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011755.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV19, O11855, P50091, Q6Q597
      UniProtKB/TrEMBL
      A6ZUP7, B3LI01, B5VJH9, C7GNJ0, C8Z9D0, N1P422
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50091.1

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