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    YAP1802 Yap1802p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853157, updated on 10-Oct-2024

    Summary

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    Official Symbol
    YAP1802
    Official Full Name
    Yap1802p
    Primary source
    SGD:S000003473
    Locus tag
    YGR241C
    See related
    AllianceGenome:SGD:S000003473; FungiDB:YGR241C; VEuPathDB:YGR241C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in endocytosis. Located in cellular bud neck; cytosol; and prospore membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YAP1802 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (974875..976581, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 6-phosphofructokinase subunit alpha Neighboring gene uncharacterized protein Neighboring gene mitochondrial pyruvate carrier Neighboring gene succinate--CoA ligase (GDP-forming) subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epsins: adaptors in endocytosis? Wendland B. Nat Rev Mol Cell Biol, 2002 Dec. PMID 12461563
    2. The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast. Sun Y, et al. PLoS Biol, 2024 Sep. PMID 39316607, Free PMC Article
    3. Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. Chi RJ, et al. J Cell Sci, 2012 Oct 15. PMID 22825870, Free PMC Article
    4. The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae. Baggett JJ, et al. Genetics, 2003 Dec. PMID 14704157, Free PMC Article
    5. The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization. Dores MR, et al. Traffic, 2010 Jan. PMID 19903324, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
      Title: The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    Yap1802p
    NP_011757.3
    • Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      974875..976581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181370.3 → NP_011757.3  TPA: Yap1802p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011757.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV22, P53309
      UniProtKB/TrEMBL
      A6ZUQ0, C8Z9D3, N1P9Z0
      Conserved Domains (1) summary
      pfam07651
      Location:5 → 263
      ANTH; ANTH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53309.1

    Gene LinkOut

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