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    NCW2 Ncw2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850891, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NCW2
    Official Full Name
    Ncw2p
    Primary source
    SGD:S000004184
    Locus tag
    YLR194C
    See related
    AllianceGenome:SGD:S000004184; FungiDB:YLR194C; VEuPathDB:YLR194C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of cell wall. Involved in fungal-type cell wall organization. Acts upstream of or within chitin localization. Located in fungal-type cell wall. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NCW2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (540809..541573, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit j Neighboring gene Ups1p Neighboring gene glycylpeptide N-tetradecanoyltransferase NMT1 Neighboring gene rRNA-processing protein PWP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The effects of the Ncw2 protein of Saccharomyces cerevisiae on the positioning of chitin in response to cell wall damage. Queiroz MG, et al. Antonie Van Leeuwenhoek, 2020 Feb. PMID 31598818
    2. NCW2, a Gene Involved in the Tolerance to Polyhexamethylene Biguanide (PHMB), May Help in the Organisation of β-1,3-Glucan Structure of Saccharomyces cerevisiae Cell Wall. Elsztein C, et al. Curr Microbiol, 2016 Sep. PMID 27246500
    3. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. Hu Z, et al. Genes Dev, 2014 Feb 15. PMID 24532716, Free PMC Article
    4. The Saccharomyces cerevisiae Ncw2 protein works on the chitin/β-glucan organisation of the cell wall. Queiroz MG, et al. Antonie Van Leeuwenhoek, 2021 Jul. PMID 33945065
    5. Up-regulation of genes encoding glycosylphosphatidylinositol (GPI)-attached proteins in response to cell wall damage caused by disruption of FKS1 in Saccharomyces cerevisiae. Terashima H, et al. Mol Gen Genet, 2000 Sep. PMID 11016834

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Saccharomyces cerevisiae Ncw2 protein works on the chitin/beta-glucan organisation of the cell wall.
      Title: The Saccharomyces cerevisiae Ncw2 protein works on the chitin/β-glucan organisation of the cell wall.
    2. NCW2 gene codes for a protein which participates in the cell wall biogenesis.
      Title: NCW2, a Gene Involved in the Tolerance to Polyhexamethylene Biguanide (PHMB), May Help in the Organisation of β-1,3-Glucan Structure of Saccharomyces cerevisiae Cell Wall.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chitin localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ncw2p
    NP_013295.1
    • GPI-anchored protein involved in cell wall remodeling; involved in the assembly of the cell wall chitin-glucan structure and repair of damage caused by the antifungal agent polyhexamethylene biguanide; role in the cell wall integrity pathway; expression is upregulated in response to cell wall stress; transported to the cell surface after Pmt1p-Pmt2p-mediated O-mannosylation, colocalizing with bud scars

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      540809..541573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182081.1 → NP_013295.1  TPA: Ncw2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013295.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYJ7, Q05777
      UniProtKB/TrEMBL
      B3RH85, B5VNB4, C7GIY1, N1NYD1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05777.1

    Gene LinkOut

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