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    COQ9 ubiquinone biosynthesis protein COQ9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850898, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COQ9
    Official Full Name
    ubiquinone biosynthesis protein COQ9
    Primary source
    SGD:S000004191
    Locus tag
    YLR201C
    See related
    AllianceGenome:SGD:S000004191; FungiDB:YLR201C; VEuPathDB:YLR201C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable lipid binding activity. Involved in ubiquinone-6 biosynthetic process. Located in mitochondrial inner membrane. Used to study coenzyme Q10 deficiency disease. Human ortholog(s) of this gene implicated in coenzyme Q10 deficiency disease and primary coenzyme Q10 deficiency 5. Orthologous to human COQ9 (coenzyme Q9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COQ9 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (549511..550293, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pba1p Neighboring gene tubulin-binding prefolding complex subunit YKE2 Neighboring gene Mss51p Neighboring gene mitochondrial 37S ribosomal protein QRI5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid. He CH, et al. Biochim Biophys Acta, 2015 Sep. PMID 26008578, Free PMC Article
    2. A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease. Duncan AJ, et al. Am J Hum Genet, 2009 May. PMID 19375058, Free PMC Article
    3. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. Tsui HS, et al. J Lipid Res, 2019 Jul. PMID 31048406, Free PMC Article
    4. Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae. Ozeir M, et al. J Biol Chem, 2015 Oct 2. PMID 26260787, Free PMC Article
    5. An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis. Lohman DC, et al. Mol Cell, 2019 Feb 21. PMID 30661980, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identify a molecular interface between COQ9 and the hydroxylase COQ7, and suggest a model whereby COQ9 presents intermediates directly to CoQ enzymes to promote biosynthesis.
      Title: An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
    2. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid.
      Title: Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid.
    3. Coq9p is a peripheral membrane protein on the matrix side of the mitochondrial inner membrane. A direct physical interaction was shown by the immunoprecipitation of HA-tagged Coq9 polypeptide with Coq4p, Coq5p, Coq6p and Coq7p.
      Title: Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.
    4. Coq9 may catalyze a reaction in the coenzyme Q biosynthetic pathway or have a regulatory role similar to that proposed for Coq8
      Title: COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in ubiquinone-6 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis protein COQ9
    NP_013302.1
    • Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      549511..550293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182088.1 → NP_013302.1  TPA: ubiquinone biosynthesis protein COQ9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013302.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYK3, Q05779
      UniProtKB/TrEMBL
      A7A190, B3RH91, B5VNB9, C7GIT2, C8ZDG7, G2WJ32, N1P6T3
      Conserved Domains (1) summary
      COG5590
      Location:11 → 255
      COG5590; Ubiquinone biosynthesis protein COQ9 [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05779.1

    Gene LinkOut

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