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    SWH1 oxysterol-binding protein related protein SWH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851286, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SWH1
    Official Full Name
    oxysterol-binding protein related protein SWH1
    Primary source
    SGD:S000000081
    Locus tag
    YAR042W
    See related
    AllianceGenome:SGD:S000000081; FungiDB:YAR042W; VEuPathDB:YAR042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OSH1; YAR044W
    Summary
    Enables lipid binding activity and sterol transfer activity. Involved in several processes, including maintenance of cell polarity; piecemeal microautophagy of the nucleus; and sterol transport. Located in several cellular components, including Golgi trans cisterna; early endosome; and nucleus-vacuole junction. Orthologous to several human genes including OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SWH1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (192619..196185)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene carnitine O-acetyltransferase YAT1 Neighboring gene uncharacterized protein Neighboring gene flocculin FLO1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Levine TP, et al. Curr Biol, 1998 Jun 18. PMID 9651677
    2. SWH1 from yeast encodes a candidate nuclear factor containing ankyrin repeats and showing homology to mammalian oxysterol-binding protein. Schmalix WA, et al. Biochim Biophys Acta, 1994 Sep 13. PMID 8086466
    3. Saccharomyces cerevisiae FLO1 Gene Demonstrates Genetic Linkage to Increased Fermentation Rate at Low Temperatures. Deed RC, et al. G3 (Bethesda), 2017 Mar 10. PMID 28143947, Free PMC Article
    4. Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. Roy A, et al. J Biol Chem, 2004 Oct 22. PMID 15271978
    5. Structure and function of nucleus-vacuole junctions: outer-nuclear-membrane targeting of Nvj1p and a role in tryptophan uptake. Kvam E, et al. J Cell Sci, 2006 Sep 1. PMID 16912077

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.
      Title: ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.
    2. Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae
      Title: Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sterol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein related protein SWH1
    NP_009421.3
    • Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats and FFAT motif; interacts with ER anchor Scs2p at the nucleus-vacuole junction; regulated by sterol binding; SWH1 has a paralog, OSH2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      192619..196185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178227.1 → NP_009421.3  TPA: oxysterol-binding protein related protein SWH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009421.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPN6, P35845, P39555, P80234, Q86ZC4, Q86ZS1
      UniProtKB/TrEMBL
      A7A0I6, C7GJW7, C8Z3J5
      Conserved Domains (7) summary
      COG0666
      Location:89 → 181
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13292
      Location:281 → 383
      PH_Osh1p_Osh2p_yeast; Yeast oxysterol binding protein homologs 1 and 2 Pleckstrin homology (PH) domain
      TIGR02169
      Location:562 → 774
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      sd00045
      Location:56 → 94
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:56 → 117
      Ank_4; Ankyrin repeats (many copies)
      pfam00023
      Location:197 → 228
      Ank; Ankyrin repeat
      pfam01237
      Location:800 → 1174
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35845.4

    Gene LinkOut

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