FAT1 long-chain fatty acid transporter FAT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FAT1
Official Full Name: long-chain fatty acid transporter FAT1
Primary source: SGD:S000000245
Locus tag: YBR041W
See related: AllianceGenome:SGD:S000000245; FungiDB:YBR041W; VEuPathDB:YBR041W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables long-chain fatty acid transporter activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid import into cell; protein quality control for misfolded or incompletely synthesized proteins; and very long-chain fatty acid metabolic process. Located in endoplasmic reticulum; lipid droplet; and peroxisome. Is intrinsic component of the cytoplasmic side of the plasma membrane. Orthologous to several human genes including SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FAT1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (318266..320275)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty Acyl Coenzyme A Synthetase Fat1p Regulates Vacuolar Structure and Stationary-Phase Lipophagy in Saccharomyces cerevisiae.
Title: Fatty Acyl Coenzyme A Synthetase Fat1p Regulates Vacuolar Structure and Stationary-Phase Lipophagy in Saccharomyces cerevisiae.
C-terminal region of Fat1p, which interacts with ACSL, is positioned on inner face of plasma membrane. Topological orientation is consistent with mechanistic roles of Fat1p in coupled transport/activation of exogenous fatty acids by vectorial acylation.
Title: Topology of the yeast fatty acid transport protein Fat1p: mechanistic implications for functional domains on the cytosolic surface of the plasma membrane.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables very long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-chain fatty acid import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein quality control for misfolded or incompletely synthesized proteins	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: long-chain fatty acid transporter FAT1

NP_009597.2

Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

318266..320275

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178389.1 → NP_009597.2 TPA: long-chain fatty acid transporter FAT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009597.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ41, O60021, P38225, Q86ZS3

UniProtKB/TrEMBL

A6ZKY5, B3LNA4, B5VE07, C7GXX1, G2W946, N1P9D0

Conserved Domains (1) summary

cd05937
Location:107 → 634

FATP_chFAT1_like; Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi