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    ECM18 alpha/beta hydrolase family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851703, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ECM18
    Official Full Name
    alpha/beta hydrolase family protein
    Primary source
    SGD:S000002532
    Locus tag
    YDR125C
    See related
    AllianceGenome:SGD:S000002532; FungiDB:YDR125C; VEuPathDB:YDR125C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable lysophosphatidic acid acyltransferase activity and phospholipase A2 activity. Predicted to be involved in cardiolipin acyl-chain remodeling; lipid homeostasis; and phosphatidic acid biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and neutral lipid storage disease. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) and ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ECM18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (701397..702758, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ino2p Neighboring gene uncharacterized protein Neighboring gene palmitoyltransferase SWF1 Neighboring gene pentafunctional protein ARO1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mating response cascade does not modulate changes in the steady-state level of target mRNAs through control of mRNA stability. Kitchen CM, et al. Yeast, 2009 May. PMID 19319831
    2. The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability. Bernal M, et al. DNA Repair (Amst), 2019 Oct. PMID 31569000
    3. Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Lussier M, et al. Genetics, 1997 Oct. PMID 9335584, Free PMC Article
    4. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Surma MA, et al. Mol Cell, 2013 Aug 22. PMID 23891562, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Jacq C, et al. Nature, 1997 May 29. PMID 9169867

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cardiolipin acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha/beta hydrolase family protein
    NP_010410.3
    • hypothetical protein; ECM18 has a paralog, ICT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      701397..702758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180433.3 → NP_010410.3  TPA: alpha/beta hydrolase family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010410.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSB1, Q04623
      UniProtKB/TrEMBL
      A6ZY87, B3LGF1, B5VG21, C8Z541, G2WAM7, N1PAD8
      Conserved Domains (1) summary
      PLN02894
      Location:112 → 442
      PLN02894; hydrolase, alpha/beta fold family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04623.1

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