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    CAD1 Cad1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852033, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAD1
    Official Full Name
    Cad1p
    Primary source
    SGD:S000002831
    Locus tag
    YDR423C
    See related
    AllianceGenome:SGD:S000002831; FungiDB:YDR423C; VEuPathDB:YDR423C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAP2
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CAD1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1318046..1319275, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Aro80p Neighboring gene Sip1p Neighboring gene dynein light chain Neighboring gene Snx41p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae. Lesuisse E, et al. Microbiology (Reading), 1995 Nov. PMID 8535522
    2. Isolation of the YAP1 homologue of Candida utilis and its use as an efficient selection marker. Iwakiri R, et al. Yeast, 2005 Oct 15. PMID 16200522
    3. Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. Cohen BA, et al. Mol Biol Cell, 2002 May. PMID 12006656, Free PMC Article
    4. The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability. Vilela C, et al. Nucleic Acids Res, 1998 Mar 1. PMID 9469820, Free PMC Article
    5. Characterization of an AP-1-like transcription factor that mediates an oxidative stress response in Kluyveromyces lactis. Billard P, et al. Mol Gen Genet, 1997 Dec. PMID 9439570

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YNL134C and YDL124W were also identified as candidate Yap2 target genes.
      Title: Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2.
    2. We conclude that specificity determinants of the Cd response are encoded within both Yap1 and Yap2 C-terminus, whereas those required for H2O2 response are only present in the Yap1 C-terminus.
      Title: The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cad1p
    NP_010711.3
    • AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1318046..1319275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180731.3 → NP_010711.3  TPA: Cad1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010711.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT53, P24813, Q02259
      UniProtKB/TrEMBL
      B3LFN3, B5VGV8, C7GTN0, N1P776
      Conserved Domains (2) summary
      cd14688
      Location:44 → 87
      bZIP_YAP; Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain
      pfam08601
      Location:355 → 406
      PAP1; Transcription factor PAP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24813.2

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