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    AST2 Ast2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856838, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AST2
    Official Full Name
    Ast2p
    Primary source
    SGD:S000000903
    Locus tag
    YER101C
    See related
    AllianceGenome:SGD:S000000903; FungiDB:YER101C; VEuPathDB:YER101C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable oxidoreductase activity. Involved in protein targeting to membrane. Located in cytoplasm. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AST2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (360502..361794, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribose phosphate diphosphokinase subunit PRS2 Neighboring gene E2 ubiquitin-conjugating protein UBC6 Neighboring gene ribosomal 40S subunit protein S8B Neighboring gene Hsp70 family chaperone SSA4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel AST2 mutation generated upon whole-genome transformation of Saccharomyces cerevisiae confers high tolerance to 5-Hydroxymethylfurfural (HMF) and other inhibitors. Vanmarcke G, et al. PLoS Genet, 2021 Oct. PMID 34624020, Free PMC Article
    2. Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. Chang A, et al. J Cell Biol, 1995 Jan. PMID 7822420, Free PMC Article
    3. Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily. Riveros-Rosas H, et al. Eur J Biochem, 2003 Aug. PMID 12899689
    4. The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators. Theis JF, et al. PLoS Genet, 2010 Dec 2. PMID 21151954, Free PMC Article
    5. Functional specialisation of yeast Rho1 GTP exchange factors. Krause SA, et al. J Cell Sci, 2012 Jun 1. PMID 22344253

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Ast2p
    NP_011027.1
    • Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      360502..361794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178992.1 → NP_011027.1  TPA: Ast2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011027.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM08, P39945
      UniProtKB/TrEMBL
      C7GVH1, G2WD22, N1P594
      Conserved Domains (1) summary
      cd08247
      Location:50 → 427
      AST1_like; AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39945.1

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