SEH1 Seh1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEH1
Official Full Name: Seh1p
Primary source: SGD:S000003068
Locus tag: YGL100W
See related: AllianceGenome:SGD:S000003068; FungiDB:YGL100W; VEuPathDB:YGL100W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to be a structural constituent of nuclear pore. Involved in positive regulation of TORC1 signaling. Is extrinsic component of fungal-type vacuolar membrane. Part of Seh1-associated complex and nuclear pore outer ring. Orthologous to human SEH1L (SEH1 like nucleoporin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEH1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (313234..314283)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we identify the Seh1-associated protein complex in yeast that contains the nucleoporins Seh1 and Sec13
Title: A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.
study determined the nucleoporin 85 (Nup85).Seh1 structure, a module in the heptameric Nup84 complex, at 3.5 angstroms resolution
Title: Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IC Inferred by Curator more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Seh1-associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Seh1-associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore outer ring	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Seh1p

NP_011415.1

Subunit of the Nup84 nuclear pore and SEACAT subcomplexes; involved in nucleocytoplasmic transport and NPC biogenesis in the nuclear pore subcomplex; subunit of SEACAT, a subcomplex of the SEA complex that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; human SEH1 homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

313234..314283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180965.1 → NP_011415.1 TPA: Seh1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU45, P53011

UniProtKB/TrEMBL

A6ZU80, B3LHG5, B5VIM5, C7GM18, C8Z8E8, G2WDZ9, N1P3I3

Conserved Domains (2) summary

sd00039
Location:13 → 53

7WD40; WD40 repeat [structural motif]

cl29593
Location:7 → 332

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...