U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    OTU2 Otu2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856373, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    OTU2
    Official Full Name
    Otu2p
    Primary source
    SGD:S000001005
    Locus tag
    YHL013C
    See related
    AllianceGenome:SGD:S000001005; FungiDB:YHL013C; VEuPathDB:YHL013C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See OTU2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (77430..78353, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S20 Neighboring gene Ylf2p Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene ribose phosphate diphosphokinase subunit PRS3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Makarova KS, et al. Trends Biochem Sci, 2000 Feb. PMID 10664582
    2. Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains. Isasa M, et al. J Proteome Res, 2015 Dec 4. PMID 26503604, Free PMC Article
    3. Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Rumpf S, et al. Mol Cell, 2006 Jan 20. PMID 16427015
    4. A balance of deubiquitinating enzymes controls cell cycle entry. Mapa CE, et al. Mol Biol Cell, 2018 Nov 15. PMID 30207830, Free PMC Article
    5. Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine. Huseinovic A, et al. Toxicol In Vitro, 2018 Mar. PMID 29258884

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Otu2p
    NP_011850.1
    • hypothetical protein; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      77430..78353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179093.1 → NP_011850.1  TPA: Otu2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKQ0, P38747
      UniProtKB/TrEMBL
      A6ZSN9, B3LSA6, B5VJR7, C7GIS4, C8ZA53, G2WF54, N1P1E6
      Conserved Domains (1) summary
      COG5539
      Location:1 → 306
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38747.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools