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    SER33 phosphoglycerate dehydrogenase SER33 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854736, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SER33
    Official Full Name
    phosphoglycerate dehydrogenase SER33
    Primary source
    SGD:S000001336
    Locus tag
    YIL074C
    See related
    AllianceGenome:SGD:S000001336; FungiDB:YIL074C; VEuPathDB:YIL074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-ketoglutarate reductase activity and phosphoglycerate dehydrogenase activity. Involved in serine family amino acid biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; amino acid metabolic disorder; primary hyperoxaluria; and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase) and PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SER33 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (221081..222490, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene coatomer subunit epsilon Neighboring gene proteasome regulatory particle base subunit RPN2 Neighboring gene Spo22p Neighboring gene Hop1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis. Paczia N, et al. Biochemistry, 2019 Jan 29. PMID 30668112
    2. The SESAME complex regulates cell senescence through the generation of acetyl-CoA. Chen W, et al. Nat Metab, 2021 Jul. PMID 34183849
    3. Linking the dynamics of chromatin occupancy and transcription with predictive models. Tran TQ, et al. Genome Res, 2021 Jun. PMID 33893157, Free PMC Article
    4. NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells. Becker-Kettern J, et al. FEBS J, 2018 Sep. PMID 30098110
    5. Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. Becker-Kettern J, et al. J Biol Chem, 2016 Mar 18. PMID 26774271, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-ketoglutarate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-ketoglutarate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables alpha-ketoglutarate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in serine family amino acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    phosphoglycerate dehydrogenase SER33
    NP_012191.1
    • 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      221081..222490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179424.1 → NP_012191.1  TPA: phosphoglycerate dehydrogenase SER33 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVL0, P40510
      UniProtKB/TrEMBL
      A0SXJ5, A6ZVJ9, B3LTS5, C7GKK5, C8ZAH1, G2WG74, N1P215
      Conserved Domains (1) summary
      PRK11790
      Location:59 → 469
      PRK11790; phosphoglycerate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40510.1

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