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    SEC28 coatomer subunit epsilon [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854734, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEC28
    Official Full Name
    coatomer subunit epsilon
    Primary source
    SGD:S000001338
    Locus tag
    YIL076W
    See related
    AllianceGenome:SGD:S000001338; FungiDB:YIL076W; VEuPathDB:YIL076W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ANU2
    Summary
    Enables promoter-specific chromatin binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; late endosome to vacuole transport via multivesicular body sorting pathway; and vesicle coating. Part of COPI vesicle coat. Colocalizes with endosome. Orthologous to human COPE (COPI coat complex subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SEC28 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (216658..217548)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene threonine--tRNA ligase THS1 Neighboring gene Rci37p Neighboring gene proteasome regulatory particle base subunit RPN2 Neighboring gene phosphoglycerate dehydrogenase SER33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes. Poulsen JW, et al. J Proteomics, 2012 Jul 16. PMID 22634085
    2. Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP. Kimata Y, et al. J Biol Chem, 2000 Apr 7. PMID 10744762
    3. epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. Duden R, et al. EMBO J, 1998 Feb 16. PMID 9463377, Free PMC Article
    4. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Hsia KC, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534429, Free PMC Article
    5. The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation. Brown CR, et al. J Biol Chem, 2008 Sep 19. PMID 18660504, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat
      Title: Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat.
    2. Vid24p and Sec28p are present at actin patches during glucose starvation.
      Title: The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation.
    3. Sec28p resides in Vid vesicles, and these vesicles converge with the endocytic pathway
      Title: The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle coating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit epsilon
    NP_012189.2
    • Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      216658..217548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179426.1 → NP_012189.2  TPA: coatomer subunit epsilon [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012189.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVK8, P40509
      UniProtKB/TrEMBL
      A6ZVJ7, B3LTS7, C7GKK7, C8ZAG9, G2WG72, N1P2J2
      Conserved Domains (1) summary
      pfam04733
      Location:4 → 293
      Coatomer_E; Coatomer epsilon subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40509.2

    Gene LinkOut

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