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    gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854728, updated on 18-Sep-2024

    Summary

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    Official Full Name
    gag-pol fusion protein
    Primary source
    SGD:S000003537
    Locus tag
    YIL082W-A
    See related
    AllianceGenome:SGD:S000003537; FungiDB:YIL082W-A; VEuPathDB:YIL082W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including DNA polymerase activity; peptidase activity; and ribonuclease activity. Predicted to be involved in transposition, RNA-mediated. Located in nucleus. Orthologous to human RTL1 (retrotransposon Gag like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (205635..210132)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Sds3p Neighboring gene phosphopantothenate--cysteine ligase CAB2 Neighboring gene tRNA-Ile Neighboring gene TRAMP complex RNA-binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ty3 nucleocapsid controls localization of particle assembly. Larsen LS, et al. J Virol, 2008 Mar. PMID 18094177, Free PMC Article
    2. TY3 GAG3 protein forms ordered particles in Escherichia coli. Larsen LS, et al. Virology, 2008 Jan 20. PMID 17964628, Free PMC Article
    3. Interaction of the Ty3 reverse transcriptase thumb subdomain with template-primer. Bibillo A, et al. J Biol Chem, 2005 Aug 26. PMID 15944162
    4. Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase. Bibillo A, et al. Nucleic Acids Res, 2005. PMID 15647500, Free PMC Article
    5. Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events. Lener D, et al. J Biol Chem, 2002 Jul 19. PMID 11994277

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrotransposition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in retrotransposon nucleocapsid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gag-pol fusion protein
    NP_012184.1
    • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      205635..210132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181434.4 → NP_012184.1  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVK4, Q04717, Q04722, Q05350, Q7LHG5
      Conserved Domains (6) summary
      cd01647
      Location:649 → 823
      RT_LTR; RT_LTR: Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the ...
      pfam03732
      Location:70 → 157
      Retrotrans_gag; Retrotransposon gag protein
      cd09274
      Location:915 → 1034
      RNase_HI_RT_Ty3; Ty3/Gypsy family of RNase HI in long-term repeat retroelements
      pfam00078
      Location:665 → 823
      RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam00665
      Location:1198 → 1306
      rve; Integrase core domain
      cl11403
      Location:286 → 462
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version

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