RAV1 Rav1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RAV1
Official Full Name: Rav1p
Primary source: SGD:S000003794
Locus tag: YJR033C
See related: AllianceGenome:SGD:S000003794; FungiDB:YJR033C; VEuPathDB:YJR033C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SOI3
Summary: Involved in early endosome to late endosome transport; regulation of protein-containing complex assembly; and vacuolar acidification. Located in cytoplasm. Is extrinsic component of membrane. Part of RAVE complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 71 and developmental and epileptic encephalopathy 81. Orthologous to several human genes including DMXL2 (Dmx like 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Rav1p interacts directly with the N-terminal domain of Vph1p.
Title: The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast.
Soi3/Rav1p is required for transport between the early endosome and the late endosome/prevacuolar compartment.
Title: Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins.
Skp1p is important for the release of Rav1p from endosomal membranes where it functions in V-ATPase assembly.
Title: Skp1p regulates Soi3p/Rav1p association with endosomal membranes but is not required for vacuolar ATPase assembly.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar acidification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RAVE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RAVE complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_012567.3

Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate

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