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    JJJ3 Jjj3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853560, updated on 18-Sep-2024

    Summary

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    Official Symbol
    JJJ3
    Official Full Name
    Jjj3p
    Primary source
    SGD:S000003858
    Locus tag
    YJR097W
    See related
    AllianceGenome:SGD:S000003858; FungiDB:YJR097W; VEuPathDB:YJR097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DPH4
    Summary
    Enables ferrous iron binding activity. Involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in cytoplasm and nucleus. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See JJJ3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (612413..612931)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Sfc1p Neighboring gene aldo-keto reductase superfamily protein Neighboring gene uncharacterized protein Neighboring gene ubiquitin-specific protease YUH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4. Thakur A, et al. J Biol Chem, 2012 Apr 13. PMID 22367199, Free PMC Article
    2. Evolutionary Conservation and Emerging Functional Diversity of the Cytosolic Hsp70:J Protein Chaperone Network of Arabidopsis thaliana. Verma AK, et al. G3 (Bethesda), 2017 Jun 7. PMID 28450372, Free PMC Article
    3. A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin. Botet J, et al. Antimicrob Agents Chemother, 2008 May. PMID 18285480, Free PMC Article
    4. Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae. Chen JY, et al. Mol Cell Biol, 1985 Dec. PMID 3915773, Free PMC Article
    5. Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast. Hawer H, et al. PLoS One, 2018. PMID 30335802, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Jjj3p
    NP_012631.3
    • Iron-binding protein; involved in targeting cytoplasmic SRP-independent proteins to the ER; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      612413..612931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181755.3 → NP_012631.3  TPA: Jjj3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012631.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR6, P47138
      UniProtKB/TrEMBL
      A6ZQ53, B3LQI2, B5VLP3, C7GMB0, C8ZBP4, G2WHA0, N1P8U0
      Conserved Domains (2) summary
      pfam00226
      Location:8 → 73
      DnaJ; DnaJ domain
      pfam05207
      Location:93 → 164
      zf-CSL; CSL zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47138.1

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