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    TFA1 transcription factor TFIIE subunit TFA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853840, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TFA1
    Official Full Name
    transcription factor TFIIE subunit TFA1
    Primary source
    SGD:S000001511
    Locus tag
    YKL028W
    See related
    AllianceGenome:SGD:S000001511; FungiDB:YKL028W; VEuPathDB:YKL028W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase II complex binding activity; TFIIH-class transcription factor complex binding activity; and single-stranded DNA binding activity. Involved in transcription open complex formation at RNA polymerase II promoter. Located in mitochondrion. Part of transcription factor TFIIE complex and transcription preinitiation complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TFA1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (385758..387206)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DNA-binding transcription repressor IXR1 Neighboring gene malate dehydrogenase (oxaloacetate-decarboxylating) Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene glutathione peroxidase GPX1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the large subunit of yeast transcription factor IIE reveals two regions with distinct functions. Kuldell NH, et al. Mol Cell Biol, 1997 Sep. PMID 9271406, Free PMC Article
    2. Promoter structure-dependent functioning of the general transcription factor IIE in Saccharomyces cerevisiae. Sakurai H, et al. J Biol Chem, 1997 Jun 20. PMID 9188494
    3. A minimal set of RNA polymerase II transcription protein interactions. Bushnell DA, et al. J Biol Chem, 1996 Aug 16. PMID 8702741
    4. Yeast TFIIE. Cloning, expression, and homology to vertebrate proteins. Feaver WJ, et al. J Biol Chem, 1994 Nov 4. PMID 7961670
    5. Purification and properties of Saccharomyces cerevisiae RNA polymerase II general initiation factor a. Sayre MH, et al. J Biol Chem, 1992 Nov 15. PMID 1429681

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to TFIIH-class transcription factor complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription open complex formation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription open complex formation at RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor TFIIE subunit TFA1
    NP_012897.3
    • TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      385758..387206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179594.3 → NP_012897.3  TPA: transcription factor TFIIE subunit TFA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012897.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXQ6, P36100
      UniProtKB/TrEMBL
      G2WI01, N1P0P6
      Conserved Domains (1) summary
      smart00531
      Location:23 → 170
      TFIIE; Transcription initiation factor IIE
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36100.1

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