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    RPL8B ribosomal 60S subunit protein L8B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850682, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPL8B
    Official Full Name
    ribosomal 60S subunit protein L8B
    Primary source
    SGD:S000003968
    Locus tag
    YLL045C
    See related
    AllianceGenome:SGD:S000003968; FungiDB:YLL045C; VEuPathDB:YLL045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KRB1; SCL41
    Summary
    Predicted to enable RNA binding activity. Involved in maturation of LSU-rRNA. Part of cytosolic large ribosomal subunit. Orthologous to human RPL7A (ribosomal protein L7a). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL8B in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (47859..48629, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene bile acid-transporting ATPase YBT1 Neighboring gene Rnp1p Neighboring gene Fps1p Neighboring gene E2-like conjugating enzyme

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KRB1, a suppressor of mak7-1 (a mutant RPL4A), is RPL4B, a second ribosomal protein L4 gene, on a fragment of Saccharomyces chromosome XII. Ohtake Y, et al. Genetics, 1995 May. PMID 7635280, Free PMC Article
    2. Evidence for a new chromosome in Saccharomyces cerevisiae. Wickner RB, et al. Mol Cell Biol, 1983 Mar. PMID 6341816, Free PMC Article
    3. Spliceosomal intronogenesis. Lee S, et al. Proc Natl Acad Sci U S A, 2016 Jun 7. PMID 27217561, Free PMC Article
    4. The organization and expression of the Saccharomyces cerevisiae L4 ribosomal protein genes and their identification as the homologues of the mammalian ribosomal protein gene L7a. Yon J, et al. Mol Gen Genet, 1991 May. PMID 2046660
    5. Mutational analysis of the ribosomal protein Rpl10 from yeast. Hofer A, et al. J Biol Chem, 2007 Nov 9. PMID 17761675

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L7 and L8 might establish RNP structures within assembling ribosomes necessary for the stable association and function of the A(3) assembly factors and for proper assembly of the neighborhoods containing domains I and II.
      Title: Ribosomal proteins L7 and L8 function in concert with six A₃ assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L8B
    NP_013055.1
    • Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8B has paralog RPL8A from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      47859..48629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181865.1 → NP_013055.1  TPA: ribosomal 60S subunit protein L8B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXW2, P29453
      UniProtKB/TrEMBL
      A7A0L4, B3LTD0, B5VMQ5, C8ZCS9, N1P6J4
      Conserved Domains (1) summary
      PTZ00365
      Location:2 → 251
      PTZ00365; 60S ribosomal protein L7Ae-like; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29453.3

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