CTF18 Ctf18p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CTF18
Official Full Name: Ctf18p
Primary source: SGD:S000004683
Locus tag: YMR078C
See related: AllianceGenome:SGD:S000004683; FungiDB:YMR078C; VEuPathDB:YMR078C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CHL12
Summary: Contributes to DNA clamp loader activity. Involved in DNA metabolic process and mitotic sister chromatid cohesion. Acts upstream of or within telomere tethering at nuclear periphery. Located in nuclear replication fork. Part of Ctf18 RFC-like complex. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CTF18 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (422503..424728, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ctf18-RFC and DNA Pol form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Title: Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
DNA polymerase epsilon outcompetes double-stranded DNA for recruiting Ctf18-RFC to the replisome.
Title: Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.
These results indicate that the Ctf18-RFC/Polepsilon interaction plays a crucial role in maintaining genome stability in budding yeast, probably through recruitment of this PCNA loader to the replication fork.
Title: Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae.
The findings indicate that the association of Ctf18-RFC with Pol at defective replication forks is a key step in activation of the S-phase checkpoint.
Title: A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.
Ctf18 confers protection against stalling or breaks at the replication fork in cells that either lack, or are compromised for, telomerase activity, which is likely to contribute another level to telomere size homeostasis.
Title: The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.
Results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring.
Title: The ELG1 clamp loader plays a role in sister chromatid cohesion.
During chromatid cohesion establishment, Ctf18 is found at the DNA replication fork.
Title: Establishment of sister chromatid cohesion at the S. cerevisiae replication fork.
Ctf18 RFC-like complex modifies telomeric chromatin to make it competent for normal localization to the nuclear periphery.
Title: The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of DNA trinucleotide repeats	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telomere tethering at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nuclear replication fork	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ctf18p

NP_013795.1

Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint