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    SPC24 kinetochore-associated Ndc80 complex subunit SPC24 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855144, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPC24
    Official Full Name
    kinetochore-associated Ndc80 complex subunit SPC24
    Primary source
    SGD:S000004723
    Locus tag
    YMR117C
    See related
    AllianceGenome:SGD:S000004723; FungiDB:YMR117C; VEuPathDB:YMR117C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to contribute to microtubule binding activity. Involved in centromere clustering and chromosome segregation. Located in kinetochore. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPC24 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (501250..501891, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mgr3p Neighboring gene ribosomal 40S subunit protein ASC1 Neighboring gene ncRNA Neighboring gene protein SHH3 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Wei RR, et al. Structure, 2006 Jun. PMID 16765893
    2. Coupling unbiased mutagenesis to high-throughput DNA sequencing uncovers functional domains in the Ndc80 kinetochore protein of Saccharomyces cerevisiae. Tien JF, et al. Genetics, 2013 Sep. PMID 23833183, Free PMC Article
    3. Architecture and flexibility of the yeast Ndc80 kinetochore complex. Wang HW, et al. J Mol Biol, 2008 Nov 21. PMID 18793650, Free PMC Article
    4. Tight bending of the Ndc80 complex provides intrinsic regulation of its binding to microtubules. Scarborough EA, et al. Elife, 2019 May 2. PMID 31045495, Free PMC Article
    5. Conserved Tetramer Junction in the Kinetochore Ndc80 Complex. Valverde R, et al. Cell Rep, 2016 Nov 15. PMID 27851957, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mislocalization of Stu2 results in premature spindle expansion in S phase stalled spc24-9 mutants.
      Title: Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.
    2. The atomic structures of the Spc24/Spc25 globular domain, determined both by X-ray crystallography at 1.9 A resolution and by NMR were reported.
      Title: Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centromere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore-associated Ndc80 complex subunit SPC24
    NP_013835.1
    • Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      501250..501891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182617.1 → NP_013835.1  TPA: kinetochore-associated Ndc80 complex subunit SPC24 [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZU0, Q04477
      UniProtKB/TrEMBL
      A6ZMH4, B3LM08, B5VPP2, C7GW93, C8ZEX0, G2WKG7, N1NXC8
      Conserved Domains (1) summary
      pfam08286
      Location:91 → 210
      Spc24; Spc24 subunit of Ndc80
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04477.1

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