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    RPL15B ribosomal 60S subunit protein L15B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855150, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPL15B
    Official Full Name
    ribosomal 60S subunit protein L15B
    Primary source
    SGD:S000004728
    Locus tag
    YMR121C
    See related
    AllianceGenome:SGD:S000004728; FungiDB:YMR121C; VEuPathDB:YMR121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. A structural constituent of ribosome. Involved in cytoplasmic translation and macroautophagy. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 12. Orthologous to human RPL15 (ribosomal protein L15). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL15B in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (509734..510348, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-protein ligase ASI1 Neighboring gene bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 Neighboring gene uncharacterized protein Neighboring gene Ncw1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of ribosomal protein L15 from Saccharomyces cerevisiae. Simoff I, et al. Curr Genet, 2009 Apr. PMID 19184027
    2. The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Mittal N, et al. Nat Commun, 2017 Sep 6. PMID 28878244, Free PMC Article
    3. A distinct nuclear import pathway used by ribosomal proteins. Rout MP, et al. Cell, 1997 May 30. PMID 9182759
    4. Binding of proteins from the large ribosomal subunits to 5.8 S rRNA of Saccharomyces cerevisiae. Lee JC, et al. J Biol Chem, 1983 Jan 25. PMID 6337137
    5. Insights into the role of yeast eIF2A in IRES-mediated translation. Reineke LC, et al. PLoS One, 2011. PMID 21915340, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of the levels of YrpL15B-mRNA in yeast cells shows that the YRPL15B gene is inactive in transcription.
      Title: Functional characterization of ribosomal protein L15 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L15B
    NP_013840.1
    • Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      509734..510348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182622.1 → NP_013840.1  TPA: ribosomal 60S subunit protein L15B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013840.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZU4, P54780
      UniProtKB/TrEMBL
      A6ZMI1, B3LM12, C7GU97, C8ZEX5, G2WIM3, G2WKH2, N1P248
      Conserved Domains (1) summary
      PTZ00026
      Location:1 → 203
      PTZ00026; 60S ribosomal protein L15; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54780.2

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