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    TFC7 transcription factor TFIIIC subunit TFC7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854277, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TFC7
    Gene description
    transcription factor TFIIIC subunit TFC7
    Primary source
    FungiDB:YOR110W
    Locus tag
    YOR110W
    See related
    SGD:S000005636; AllianceGenome:SGD:S000005636; VEuPathDB:YOR110W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatase activity. Contributes to DNA binding activity and RNA polymerase III general transcription initiation factor activity. Involved in 5S class rRNA transcription by RNA polymerase III and dephosphorylation. Part of transcription factor TFIIIC complex. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TFC7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (528941..530248)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene 2-isopropylmalate synthase LEU9 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 Neighboring gene nucleotide diphosphatase Neighboring gene Cex1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detection of modifications in the glucose metabolism induced by genetic mutations in Saccharomyces cerevisiae by 13C- and H-NMR spectroscopy. Herve M, et al. Eur J Biochem, 2000 Jun. PMID 10824121
    2. Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. Taylor NM, et al. J Biol Chem, 2013 May 24. PMID 23569204, Free PMC Article
    3. A truncation mutant of the 95-kilodalton subunit of transcription factor IIIC reveals asymmetry in Ty3 integration. Aye M, et al. Mol Cell Biol, 2001 Nov. PMID 11604518, Free PMC Article
    4. A suppressor of mutations in the class III transcription system encodes a component of yeast TFIIIB. Rüth J, et al. EMBO J, 1996 Apr 15. PMID 8617241, Free PMC Article
    5. Saccharomyces cerevisiae transcription factors IIIB and IIIC bend the DNA of a tRNA(Gln) gene. Léveillard T, et al. J Biol Chem, 1991 Mar 15. PMID 2002052

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III general transcription initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor TFIIIC subunit TFC7
    NP_014753.1
    • RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      528941..530248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183529.1 → NP_014753.1  TPA: transcription factor TFIIIC subunit TFC7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2G9, Q07347, Q12415, Q6B220
      UniProtKB/TrEMBL
      A0A6A5Q3K1, B3LJF3, B5VS00, C7GMM6, C8ZI72, G2WMY6, N1NWY5
      Conserved Domains (2) summary
      COG0406
      Location:5 → 186
      PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
      pfam10419
      Location:289 → 368
      TFIIIC_sub6; TFIIIC subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12415.1

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