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    ESA1 NuA4 histone acetyltransferase complex catalytic subunit ESA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854418, updated on 14-Aug-2024

    Summary

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    Gene symbol
    ESA1
    Gene description
    NuA4 histone acetyltransferase complex catalytic subunit ESA1
    Primary source
    FungiDB:YOR244W
    Locus tag
    YOR244W
    See related
    SGD:S000005770; AllianceGenome:SGD:S000005770; VEuPathDB:YOR244W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAT5; TAS1
    Summary
    Enables H4 histone acetyltransferase activity; histone crotonyltransferase activity; and transcription coregulator activity. Involved in several processes, including chromatin organization; nucleic acid metabolic process; and positive regulation of transcription elongation from RNA polymerase II promoter. Located in chromatin. Part of Piccolo NuA4 histone acetyltransferase complex. Used to study cancer. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ESA1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (792531..793868)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ssp2p Neighboring gene pseudouridine synthase PUS7 Neighboring gene diacylglycerol O-acyltransferase Neighboring gene Env9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small molecule inhibitors of histone acetyltransferase Tip60. Wu J, et al. Bioorg Chem, 2011 Feb. PMID 21186043, Free PMC Article
    2. Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. Shimojo H, et al. J Mol Biol, 2008 May 16. PMID 18407291
    3. Catalytic mechanism of a MYST family histone acetyltransferase. Berndsen CE, et al. Biochemistry, 2007 Jan 23. PMID 17223684, Free PMC Article
    4. The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Yan Y, et al. Nat Struct Biol, 2002 Nov. PMID 12368900
    5. Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Reid JL, et al. Mol Cell, 2000 Dec. PMID 11163204

    See all (176) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism.
      Title: Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism.
    2. Structure of the NuA4 histone acetyltransferase complex.
      Title: Structure of the NuA4 histone acetyltransferase complex.
    3. Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
      Title: Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
    4. A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.
      Title: A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.
    5. Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
      Title: Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
    6. Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
      Title: Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
    7. ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
      Title: ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
    8. Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins.
      Title: Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins.
    9. Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.
      Title: Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.
    10. Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
      Title: Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K16 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone crotonyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide 2-hydroxyisobutyryltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide crotonyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated transcription elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated transcription elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of piccolo histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NuA4 histone acetyltransferase complex catalytic subunit ESA1
    NP_014887.3
    • Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      792531..793868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183663.3 → NP_014887.3  TPA: NuA4 histone acetyltransferase complex catalytic subunit ESA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014887.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2U6, Q08649
      UniProtKB/TrEMBL
      A6ZP83, B3LJR3, C7GWE4, C8ZGZ6, G2WNB2, N1NWU8
      Conserved Domains (1) summary
      COG5027
      Location:16 → 431
      SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08649.1

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