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    GSH2 glutathione synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854108, updated on 17-May-2024

    Summary

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    Gene symbol
    GSH2
    Gene description
    glutathione synthase
    Primary source
    FungiDB:YOL049W
    Locus tag
    YOL049W
    See related
    SGD:S000005409; AllianceGenome:SGD:S000005409; VEuPathDB:YOL049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutathione synthase activity. Involved in glutathione biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and hemolytic anemia due to glutathione synthetase deficiency. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GSH2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (238619..240094)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Gal11p Neighboring gene Rrt8p Neighboring gene Lds2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cadmium-glutathione solution structures provide new insights into heavy metal detoxification. Delalande O, et al. FEBS J, 2010 Dec. PMID 21078121
    2. Isolation and properties of yeast glutathione synthetase. SNOKE JE. J Biol Chem, 1955 Apr. PMID 14367342
    3. Large conformational changes in the catalytic cycle of glutathione synthase. Gogos A, et al. Structure, 2002 Dec. PMID 12467574
    4. Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae. Inoue Y, et al. Biochim Biophys Acta, 1998 Feb 11. PMID 9512666
    5. Nickel Oxide (NiO) Nanoparticles Induce Loss of Cell Viability in Yeast Mediated by Oxidative Stress. Sousa CA, et al. Chem Res Toxicol, 2018 Aug 20. PMID 30043610

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GSH1 and GSH2 gene mutations affect glutathione synthetase activity in Saccharomyces cerevisiae.
      Title: Effects of GSH1 and GSH2 Gene Mutation on Glutathione Synthetases Activity of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione synthase
    NP_014593.1
    • Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      238619..240094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183303.1 → NP_014593.1  TPA: glutathione synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014593.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W218, Q08220
      UniProtKB/TrEMBL
      A0A8H4BVU3, B3LJ10, C7GK17, C8ZHR5, E9P9L9, N1P2R6
      Conserved Domains (1) summary
      TIGR01986
      Location:11 → 490
      glut_syn_euk; glutathione synthetase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08220.1

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