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    Nat8b N-acetyltransferase 8B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171084, updated on 17-Aug-2024

    Summary

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    Symbol
    Nat8bprovided by RGD
    Full Name
    N-acetyltransferase 8Bprovided by RGD
    Primary source
    RGD:621605
    See related
    EnsemblRapid:ENSRNOG00000056962 AllianceGenome:RGD:621605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cml1; Cml6; Nat8; RGD621605
    Summary
    Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to be involved in several processes, including amyloid-beta metabolic process; negative regulation of apoptotic process; and peptidyl-lysine N6-acetylation. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 708.6), Liver (RPKM 50.1) and 5 other tissues See more
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    Genomic context

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    Location:
    4q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119916909..119923544, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118359445..118364351, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117606022..117607366, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene Tp53rk binding protein Neighboring gene dual specificity phosphatase 11 Neighboring gene uncharacterized LOC102549328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. Ko MH, et al. J Biol Chem, 2009 Jan 23. PMID 19011241, Free PMC Article
    2. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. Mak AB, et al. J Mol Biol, 2014 May 29. PMID 24556617, Free PMC Article
    3. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Popsueva AE, et al. Dev Biol, 2001 Jun 15. PMID 11397015
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Clone Names

    • MGC93215

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gastrulation with mouth forming second NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable N-acetyltransferase 8B
    Names
    camello-like 1 like
    camello-like protein 1
    camello-like protein 6
    probable N-acetyltransferase CML6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133558.2 → NP_598242.1  probable N-acetyltransferase 8B

      See identical proteins and their annotated locations for NP_598242.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q9JIY6
      UniProtKB/TrEMBL
      A6IAU4
      Related
      ENSRNOP00000068791.1, ENSRNOT00000088557.3
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      119916909..119923544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106980.2 → XP_038962908.1  probable N-acetyltransferase 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9JIY6
      UniProtKB/TrEMBL
      A6IAU4
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. XM_008763107.4 → XP_008761329.1  probable N-acetyltransferase 8B isoform X1

      See identical proteins and their annotated locations for XP_008761329.1

      UniProtKB/Swiss-Prot
      Q9JIY6
      UniProtKB/TrEMBL
      A6IAU4
      Related
      ENSRNOP00000078918.1, ENSRNOT00000096643.2
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family

    3. XM_017593010.3 → XP_017448499.1  probable N-acetyltransferase 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9JIY6
      UniProtKB/TrEMBL
      A6IAU4
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family

    4. XM_008763105.4 → XP_008761327.1  probable N-acetyltransferase 8B isoform X1

      See identical proteins and their annotated locations for XP_008761327.1

      UniProtKB/Swiss-Prot
      Q9JIY6
      UniProtKB/TrEMBL
      A6IAU4
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIY6.1 GenPept UniProtKB/Swiss-Prot:Q9JIY6

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