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    Chn1 chimerin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84030, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Chn1provided by RGD
    Official Full Name
    chimerin 1provided by RGD
    Primary source
    RGD:620139
    See related
    EnsemblRapid:ENSRNOG00000017939 AllianceGenome:RGD:620139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and ephrin receptor binding activity. Predicted to be involved in ephrin receptor signaling pathway; motor neuron axon guidance; and regulation of axonogenesis. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to human CHN1 (chimerin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 314.3), Lung (RPKM 36.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chn1 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78917329..79084040, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58509822..58676462, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60512360..60668413, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic alpha 1 subunit Neighboring gene uncharacterized LOC134486115 Neighboring gene serpin family B member 8 like 1 Neighboring gene uncharacterized LOC134486114 Neighboring gene uncharacterized LOC120101570 Neighboring gene RNA, U6 small nuclear 1136 Neighboring gene ubiquitin-conjugating enzyme E2S, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons. Marland JR, et al. J Biol Chem, 2011 Jan 7. PMID 21056981, Free PMC Article
    2. Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. Brown M, et al. J Neurosci, 2004 Oct 13. PMID 15483118, Free PMC Article
    3. Expression and regulation of chemerin during rat pregnancy. Garces MF, et al. Placenta, 2012 May. PMID 22369992
    4. Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. Shi L, et al. Proc Natl Acad Sci U S A, 2007 Oct 9. PMID 17911252, Free PMC Article
    5. Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. Lim HH, et al. Biochem J, 1992 Oct 15. PMID 1445199, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. serum levels decreased significantly as gestation progressed
      Title: Expression and regulation of chemerin during rat pregnancy.
    2. signaling via diacylglycerol may regulate the abundance of alpha1-chimaerin under physiological conditions
      Title: Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.
    3. identified a new alpha2-chimaerin-dependent signaling mechanism through which EphA4 transduces its signals to the actin cytoskeleton and modulates growth cone morphology
      Title: Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.
    4. These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling.
      Title: Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phorbol ester receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in motor neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-chimaerin
    Names
    A-chimaerin
    N-chimerin
    NC
    alpha-chimerin
    chimerin (chimaerin) 1
    rho GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399177.1 → NP_001386106.1  N-chimaerin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000081883.2, ENSRNOT00000099938.2

    2. NM_032083.2 → NP_114472.2  N-chimaerin isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC094519, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P30337, Q505J4
      UniProtKB/TrEMBL
      A6HMA4
      Conserved Domains (2) summary
      cd04372
      Location:141 → 334
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:77 → 135
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      78917329..79084040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105973.2 → XP_038961901.1  N-chimaerin isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHR6, A0A8I6ASS0
      Related
      ENSRNOP00000097347.1, ENSRNOT00000102775.2
      Conserved Domains (3) summary
      cd10352
      Location:38 → 124
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:262 → 455
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:197 → 253
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    2. XM_006234386.5 → XP_006234448.1  N-chimaerin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A036
      Related
      ENSRNOP00000098759.1, ENSRNOT00000140416.1
      Conserved Domains (3) summary
      cd10352
      Location:59 → 145
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:283 → 476
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:223 → 275
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_063284708.1 → XP_063140778.1  N-chimaerin isoform X3

      Related
      ENSRNOP00000060544.5, ENSRNOT00000068745.5

    4. XM_063284709.1 → XP_063140779.1  N-chimaerin isoform X4

    RNA

    1. XR_010064703.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30337.2 GenPept UniProtKB/Swiss-Prot:P30337

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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