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    Ltbp2 latent transforming growth factor beta binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59106, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ltbp2provided by RGD
    Official Full Name
    latent transforming growth factor beta binding protein 2provided by RGD
    Primary source
    RGD:68380
    See related
    EnsemblRapid:ENSRNOG00000012094 AllianceGenome:RGD:68380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microfibril binding activity. Involved in response to alkaloid. Predicted to be located in extracellular region. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and megalocornea. Orthologous to human LTBP2 (latent transforming growth factor beta binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 323.1), Heart (RPKM 60.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ltbp2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110161029..110261586, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104429947..104530498, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108500114..108596653, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene NPC intracellular cholesterol transporter 2 Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene Fcf1 rRNA-processing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure. Park S, et al. JACC Basic Transl Sci, 2020 May. PMID 32478206, Free PMC Article
    2. TGF-beta1-dependent differential expression of a rat homolog for latent TGF-beta binding protein in astrocytes and C6 glioma cells. Krohn K. Glia, 1999 Feb 15. PMID 10028916
    3. LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy. Pang XF, et al. Acta Physiol (Oxf), 2020 Mar. PMID 31512380
    4. Identification of differentially expressed genes and preliminary validations in cardiac pathological remodeling induced by transverse aortic constriction. Wang HB, et al. Int J Mol Med, 2019 Oct. PMID 31364721, Free PMC Article
    5. Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities. Potus F, et al. Int J Mol Sci, 2018 Sep 12. PMID 30213070, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell proliferation and vascular remodeling in a rat model of intracranial aneurysm.
      Title: LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell proliferation and vascular remodeling in a rat model of intracranial aneurysm.
    2. LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy.
      Title: LTBP2 knockdown by siRNA reverses myocardial oxidative stress injury, fibrosis and remodelling during dilated cardiomyopathy.
    3. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
      Title: Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfibril binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in supramolecular fiber organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    latent-transforming growth factor beta-binding protein 2
    Names
    LTBP-2 like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021586.2 → NP_067597.2  latent-transforming growth factor beta-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      CK358810, CK479508, DV213994, Y12760
      UniProtKB/TrEMBL
      A6JDY9, F1M7L7
      Related
      ENSRNOP00000038437.3, ENSRNOT00000031331.6
      Conserved Domains (4) summary
      smart00179
      Location:1269 → 1302
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:897 → 931
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:689 → 725
      TB; TB domain
      pfam07645
      Location:1145 → 1184
      EGF_CA; Calcium-binding EGF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110161029..110261586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240350.5 → XP_006240412.1  latent-transforming growth factor beta-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006240412.1

      UniProtKB/TrEMBL
      A0A0G2K1G5, A0A8I6A5Z7, A6JDZ0
      Related
      ENSRNOP00000071831.1, ENSRNOT00000082792.3
      Conserved Domains (4) summary
      smart00179
      Location:1313 → 1346
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:897 → 931
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:1433 → 1468
      TB; TB domain
      pfam07645
      Location:1145 → 1184
      EGF_CA; Calcium-binding EGF domain

    2. XM_039112809.2 → XP_038968737.1  latent-transforming growth factor beta-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5Z7
      Conserved Domains (5) summary
      smart00179
      Location:1272 → 1305
      EGF_CA; Calcium-binding EGF-like domain
      PHA03378
      Location:756 → 854
      PHA03378; EBNA-3B; Provisional
      cd00054
      Location:897 → 931
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:1104 → 1143
      EGF_CA; Calcium-binding EGF domain
      pfam00683
      Location:689 → 731
      TB; TB domain

    3. XM_039112808.2 → XP_038968736.1  latent-transforming growth factor beta-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JDY9, F1M7L7
      Conserved Domains (5) summary
      smart00179
      Location:1272 → 1305
      EGF_CA; Calcium-binding EGF-like domain
      PHA03378
      Location:756 → 854
      PHA03378; EBNA-3B; Provisional
      cd00054
      Location:897 → 931
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:1061 → 1101
      EGF_CA; Calcium-binding EGF domain
      pfam00683
      Location:689 → 731
      TB; TB domain

    4. XM_063262384.1 → XP_063118454.1  latent-transforming growth factor beta-binding protein 2 isoform X5

      Related
      ENSRNOP00000106048.1, ENSRNOT00000127640.1

    5. XM_063262382.1 → XP_063118452.1  latent-transforming growth factor beta-binding protein 2 isoform X4

      Related
      ENSRNOP00000075533.2, ENSRNOT00000077458.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35806.1 GenPept UniProtKB/Swiss-Prot:O35806

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