Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp3a9provided by RGD
Official Full Name: cytochrome P450, family 3, subfamily a, polypeptide 9provided by RGD
Primary source: RGD:708392
See related: EnsemblRapid:ENSRNOG00000046643 AllianceGenome:RGD:708392
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp3a13; P450olf3
Summary: Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough) and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 464.2) See more
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Genomic context

Location:: 12q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (21919955..21960160, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16806222..16846428, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19074288..19114491, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP-dependent metabolism of gamma-tocopherol and tocotrienol is a critical determinant of their concentrations in the serum and tissues. Some amount of dietary vitamin E isoform is metabolized by a CYP-mediated pathway in the intestine during absorption.
Title: Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats.
female rats have 28-fold higher CYP3A9 mRNA levels than males in liver and 3.8-fold higher in lung
Title: Insights into gender bias: rat cytochrome P450 3A9.
Although CYP3A9 is predominantly expressed in the female rat liver, its expression in the intestine is not different between the two sexes. CYP3A9 is involved in the intestinal metabolism of CYP3A substrates in both sexes.
Title: Intestinal expression and metabolic activity of the CYP3A subfamily in female rats.
characterization of the active site of CYP3A9 and comparison to its human ortholog
Title: Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase.
1,25-dihydroxyvitamin D2 specifically induces CYP3A9 in rat intestine more strongly than 1,25-dihydroxyvitamin D3 in vivo and in vitro.
Title: 19nor-1,25-dihydroxyvitamin D2 specifically induces CYP3A9 in rat intestine more strongly than 1,25-dihydroxyvitamin D3 in vivo and in vitro.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132022 (e-PCR)
- UniSTS:215305

Cyp3a13 (e-PCR), detects polymorphism
- UniSTS:463003

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables steroid hydroxylase activity	TAS Traceable Author Statement more info	PubMed
enables testosterone 6-beta-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in alkaloid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 3A9

Names: 3AH15; CYPIIIA9; P450-OLF3; cytochrome P450 olfactive 3; cytochrome P450, family 3, subfamily a, polypeptide 13; cytochrome P450-OLF3; olfactive; olfactory cytochrome P450olf3

NP_671739.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.