Tg thyroglobulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tgprovided by RGD
Full Name: thyroglobulinprovided by RGD
Primary source: RGD:3848
See related: Ensembl:ENSRNOG00000006104 AllianceGenome:RGD:3848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tgn
Summary: Enables several functions, including anion binding activity; chaperone binding activity; and identical protein binding activity. Involved in several processes, including response to lipopolysaccharide; thyroid hormone generation; and transcytosis. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypothyroidism and isolated growth hormone deficiency. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 16.1), Kidney (RPKM 5.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (100307349..100492246)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (98418293..98603210)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (107467260..107652897)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
Title: The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
Title: Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.
Title: p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.
SREBP1c and SREBP2 are transcriptional regulators of the thyroglobulin gene in thyroid cells.
Title: Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells.
cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways
Title: Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.
Rab7 regulates CDH1 endocytosis, circular dorsal ruffles genesis, and thyroglobulin pinocytosis in a thyroid cell line.
Title: Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line.
Tg possesses unique means of regulating cell proliferation that are dependent on miR-24 and that could conceivably be involved in the autoregulation of thyroid function by Tg.
Title: Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs.
A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
Title: A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
Aammonium perchlorate can decrease the mRNA expression levels of Tg and TPO in the thyroid.
Title: [The effects of ammonium perchlorate on thyroid function and mRNA expression of thyroglobulin and thyroperoxidase].
Compared with the control group, the TPO mRNA levels of the propylthiouracil-treated group were increased, while the Tg mRNA levels were decreased significantly.
Title: [Effect of PTU on the expression of thyroid TPO, Tg mRNA in rats].

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sla (e-PCR), detects polymorphism
- UniSTS:144406

D7Got78 (e-PCR)
- UniSTS:114492

RH132711 (e-PCR)
- UniSTS:215994

RH141175 (e-PCR)
- UniSTS:223171

d7rat134 (e-PCR)
- UniSTS:122319

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables anion binding	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to genistein	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in iodide transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iodide transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone generation	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thyroglobulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270783.1 → NP_001257712.1 thyroglobulin isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2JXY8, G5ENA7

Related

ENSRNOP00000070452.1, ENSRNOT00000077382.3

Conserved Domains (5) summary

smart00211
Location:1471 → 1518

TY; Thyroglobulin type I repeats

cd00191
Location:96 → 161

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam00135
Location:2150 → 2671

COesterase; Carboxylesterase family

pfam07699
Location:1416 → 1461

GCC2_GCC3; GCC2 and GCC3

cl00150
Location:682 → 728

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
NM_001270784.1 → NP_001257713.1 thyroglobulin isoform 3 precursor

See identical proteins and their annotated locations for NP_001257713.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) consists of only the first five exons plus an alternate 3' exon compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus compared to isoform 1. This variant has been described in PMID:2325666.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6AAP3, A6HRR7

Related

ENSRNOP00000089860.1, ENSRNOT00000083264.3

Conserved Domains (1) summary

cd00191
Location:96 → 161

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
NM_030988.2 → NP_112250.2 thyroglobulin isoform 1 precursor

See identical proteins and their annotated locations for NP_112250.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P06882, Q9JKY6, Q9JM94

UniProtKB/TrEMBL

A6HRR6, G3V6V3

Related

ENSRNOP00000009241.2, ENSRNOT00000009240.7

Conserved Domains (5) summary

smart00211
Location:1519 → 1566

TY; Thyroglobulin type I repeats

cd00191
Location:96 → 161

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam00135
Location:2198 → 2719

COesterase; Carboxylesterase family

pfam07699
Location:1464 → 1509

GCC2_GCC3; GCC2 and GCC3

cl00150
Location:164 → 249

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases