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    Nrcam neuronal cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497815, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nrcamprovided by RGD
    Official Full Name
    neuronal cell adhesion moleculeprovided by RGD
    Primary source
    RGD:3209
    See related
    EnsemblRapid:ENSRNOG00000004067 AllianceGenome:RGD:3209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ankyrin binding activity and protein binding activity involved in heterotypic cell-cell adhesion. Predicted to be involved in several processes, including angiogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; and neuron development. Predicted to act upstream of or within several processes, including neuronal action potential propagation; regulation of neuron projection development; and retinal ganglion cell axon guidance. Located in axon initial segment and node of Ranvier. Orthologous to human NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 599.3) and Adrenal (RPKM 228.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrcam in Genome Data Viewer
    Location:
    6q21
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (67129723..67425510)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61402813..61698536)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (64297843..64867408)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 4 Neighboring gene patatin-like phospholipase domain containing 8 Neighboring gene U6 spliceosomal RNA Neighboring gene G patch domain-containing protein 4, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alternative RNA splicing associated with axon regeneration after rat peripheral nerve injury. Mao S, et al. Exp Neurol, 2018 Oct. PMID 29981323
    2. NrCAM coupling to the cytoskeleton depends on multiple protein domains and partitioning into lipid rafts. Falk J, et al. Mol Biol Cell, 2004 Oct. PMID 15254265, Free PMC Article
    3. Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule. Davey F, et al. J Neurochem, 2005 Sep. PMID 15992371
    4. Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. Davis JQ, et al. J Biol Chem, 1994 Nov 4. PMID 7961622
    5. Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. Davis JQ, et al. J Cell Biol, 1996 Dec. PMID 8947556, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We identified a key alternative splicing event of Nrcam (Nrcam-S) as an important candidate in promoting axon regeneration
      Title: Alternative RNA splicing associated with axon regeneration after rat peripheral nerve injury.
    2. This is the first interaction reported for NrCAM, and its association with SAP102 suggests that it is part of a larger complex which can interact with many different signalling pathways.
      Title: Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule.
    3. Results suggest that anchoring of NrCAM with retrograde actin flow can be triggered by adhesive contacts via cooperative processes.
      Title: NrCAM coupling to the cytoskeleton depends on multiple protein domains and partitioning into lipid rafts.
    4. Gliomedin, a Schwann cell ligand for both neurofascin and Nrcam that is localized to the nodal microvilli from the onset of myelination.
      Title: Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ankyrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ankyrin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding involved in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding involved in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in clustering of voltage-gated sodium channels IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within clustering of voltage-gated sodium channels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clustering of voltage-gated sodium channels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clustering of voltage-gated sodium channels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal action potential propagation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuronal action potential propagation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal ganglion cell axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retinal ganglion cell axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in node of Ranvier IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuronal cell adhesion molecule
    Names
    ankyrin-binding cell adhesion molecule NrCAM
    neuron-glia-CAM-related cell adhesion molecule
    neuronal surface protein Bravo
    ng-CAM-related
    ngCAM-related cell adhesion molecule
    nr-CAM
    rBravo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013150.3 → NP_037282.2  neuronal cell adhesion molecule precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K498, D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      smart00408
      Location:285 → 347
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:1079 → 1143
      FN3; Fibronectin type 3 domain
      smart00409
      Location:552 → 633
      IG; Immunoglobulin
      smart00410
      Location:367 → 449
      IG_like; Immunoglobulin like
      cd00063
      Location:647 → 737
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:288 → 292
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      67129723..67425510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262283.1 → XP_063118353.1  neuronal cell adhesion molecule isoform X42

    2. XM_063262272.1 → XP_063118342.1  neuronal cell adhesion molecule isoform X31

    3. XM_063262274.1 → XP_063118344.1  neuronal cell adhesion molecule isoform X33

    4. XM_063262275.1 → XP_063118345.1  neuronal cell adhesion molecule isoform X35

      Related
      ENSRNOP00000098337.2, ENSRNOT00000120706.2

    5. XM_063262280.1 → XP_063118350.1  neuronal cell adhesion molecule isoform X40

    6. XM_039112675.2 → XP_038968603.1  neuronal cell adhesion molecule isoform X1

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      cd00063
      Location:651 → 741
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:957 → 1041
      fn3; Fibronectin type III domain
      pfam13882
      Location:1198 → 1283
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:382 → 386
      Ig; Ig strand B [structural motif]
      cd05874
      Location:50 → 144
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:366 → 454
      Ig; Immunoglobulin domain

    7. XM_063262268.1 → XP_063118338.1  neuronal cell adhesion molecule isoform X12

    8. XM_017594282.3 → XP_017449771.1  neuronal cell adhesion molecule isoform X15

      UniProtKB/Swiss-Prot
      P97686

    9. XM_017594288.3 → XP_017449777.1  neuronal cell adhesion molecule isoform X19

      UniProtKB/TrEMBL
      D4A8C2, Q6PW38

    10. XM_017594273.3 → XP_017449762.1  neuronal cell adhesion molecule isoform X3

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34

    11. XM_017594283.3 → XP_017449772.1  neuronal cell adhesion molecule isoform X16

      UniProtKB/Swiss-Prot
      P97686

    12. XM_063262264.1 → XP_063118334.1  neuronal cell adhesion molecule isoform X5

    13. XM_017594289.3 → XP_017449778.1  neuronal cell adhesion molecule isoform X20

      UniProtKB/TrEMBL
      Q6PW35

    14. XM_063262269.1 → XP_063118339.1  neuronal cell adhesion molecule isoform X24

    15. XM_039112699.2 → XP_038968627.1  neuronal cell adhesion molecule isoform X26

      UniProtKB/TrEMBL
      Q6PW35
      Conserved Domains (6) summary
      cd00063
      Location:641 → 731
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:947 → 1031
      fn3; Fibronectin type III domain
      pfam13882
      Location:1080 → 1165
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:382 → 386
      Ig; Ig strand B [structural motif]
      cd05874
      Location:50 → 144
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:366 → 454
      Ig; Immunoglobulin domain

    16. XM_063262273.1 → XP_063118343.1  neuronal cell adhesion molecule isoform X32

    17. XM_039112684.2 → XP_038968612.1  neuronal cell adhesion molecule isoform X7

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      cd00063
      Location:632 → 722
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:938 → 1022
      fn3; Fibronectin type III domain
      pfam13882
      Location:1176 → 1261
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:363 → 367
      Ig; Ig strand B [structural motif]
      cd05874
      Location:50 → 144
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:347 → 435
      Ig; Immunoglobulin domain

    18. XM_039112695.2 → XP_038968623.1  neuronal cell adhesion molecule isoform X23

      UniProtKB/Swiss-Prot
      P97686
      Conserved Domains (6) summary
      cd00063
      Location:632 → 722
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:938 → 1022
      fn3; Fibronectin type III domain
      pfam13882
      Location:1083 → 1168
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:363 → 367
      Ig; Ig strand B [structural motif]
      cd05874
      Location:50 → 144
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:347 → 435
      Ig; Immunoglobulin domain

    19. XM_063262266.1 → XP_063118336.1  neuronal cell adhesion molecule isoform X10

    20. XM_063262276.1 → XP_063118346.1  neuronal cell adhesion molecule isoform X37

    21. XM_063262277.1 → XP_063118347.1  neuronal cell adhesion molecule isoform X38

    22. XM_039112676.2 → XP_038968604.1  neuronal cell adhesion molecule isoform X4

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      cd00063
      Location:647 → 737
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:953 → 1037
      fn3; Fibronectin type III domain
      pfam13882
      Location:1194 → 1279
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:378 → 382
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:362 → 450
      Ig; Immunoglobulin domain

    23. XM_017594284.3 → XP_017449773.1  neuronal cell adhesion molecule isoform X17

      UniProtKB/Swiss-Prot
      P97686
      UniProtKB/TrEMBL
      A0A8J8YHB8
      Related
      ENSRNOP00000056494.5, ENSRNOT00000059739.8

    24. XM_017594290.3 → XP_017449779.1  neuronal cell adhesion molecule isoform X21

      UniProtKB/TrEMBL
      A0A1W5DU98, D4A8C2, Q6PW38
      Related
      ENSRNOP00000044341.6, ENSRNOT00000050222.10

    25. XM_017594272.3 → XP_017449761.1  neuronal cell adhesion molecule isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW27, D3ZXM9, Q6PW34
      Related
      ENSRNOP00000098312.2, ENSRNOT00000120680.2

    26. XM_017594285.3 → XP_017449774.1  neuronal cell adhesion molecule isoform X18

      UniProtKB/Swiss-Prot
      P97686
      Related
      ENSRNOP00000072959.3, ENSRNOT00000083088.5

    27. XM_063262265.1 → XP_063118335.1  neuronal cell adhesion molecule isoform X6

    28. XM_017594291.3 → XP_017449780.1  neuronal cell adhesion molecule isoform X22

      UniProtKB/TrEMBL
      Q6PW35

    29. XM_039112701.2 → XP_038968629.1  neuronal cell adhesion molecule isoform X28

      UniProtKB/TrEMBL
      D4A8C2, Q6PW38
      Conserved Domains (6) summary
      cd00063
      Location:637 → 727
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:943 → 1027
      fn3; Fibronectin type III domain
      pfam13882
      Location:1079 → 1164
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:378 → 382
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:362 → 450
      Ig; Immunoglobulin domain

    30. XM_039112702.2 → XP_038968630.1  neuronal cell adhesion molecule isoform X30

      UniProtKB/TrEMBL
      Q6PW35
      Conserved Domains (6) summary
      cd00063
      Location:637 → 727
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:943 → 1027
      fn3; Fibronectin type III domain
      pfam13882
      Location:1076 → 1161
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:378 → 382
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:362 → 450
      Ig; Immunoglobulin domain

    31. XM_039112685.2 → XP_038968613.1  neuronal cell adhesion molecule isoform X8

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1175 → 1260
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    32. XM_039112696.2 → XP_038968624.1  neuronal cell adhesion molecule isoform X25

      UniProtKB/Swiss-Prot
      P97686
      UniProtKB/TrEMBL
      A0A8I6ADS1
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1082 → 1167
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    33. XM_039112705.2 → XP_038968633.1  neuronal cell adhesion molecule isoform X34

      UniProtKB/TrEMBL
      D4A8C2, Q6PW38
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1070 → 1155
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    34. XM_039112686.2 → XP_038968614.1  neuronal cell adhesion molecule isoform X9

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1172 → 1257
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    35. XM_039112690.2 → XP_038968618.1  neuronal cell adhesion molecule isoform X14

      UniProtKB/TrEMBL
      D3ZXM9, Q6PW34
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1130 → 1215
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    36. XM_039112700.2 → XP_038968628.1  neuronal cell adhesion molecule isoform X27

      UniProtKB/Swiss-Prot
      P97686
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1079 → 1164
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    37. XM_063262267.1 → XP_063118337.1  neuronal cell adhesion molecule isoform X11

    38. XM_039112707.2 → XP_038968635.1  neuronal cell adhesion molecule isoform X36

      UniProtKB/TrEMBL
      Q6PW35
      Conserved Domains (6) summary
      cd00063
      Location:628 → 718
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:934 → 1018
      fn3; Fibronectin type III domain
      pfam13882
      Location:1067 → 1152
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:359 → 363
      Ig; Ig strand B [structural motif]
      cd05874
      Location:46 → 140
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:343 → 431
      Ig; Immunoglobulin domain

    39. XM_063262270.1 → XP_063118340.1  neuronal cell adhesion molecule isoform X29

    40. XM_039112689.2 → XP_038968617.1  neuronal cell adhesion molecule isoform X13

      UniProtKB/TrEMBL
      A0A0G2K3Q5, A6HBE7
      Related
      ENSRNOP00000098339.2, ENSRNOT00000120708.2
      Conserved Domains (6) summary
      cd00063
      Location:641 → 731
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:947 → 1031
      fn3; Fibronectin type III domain
      pfam13882
      Location:1143 → 1228
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:372 → 376
      Ig; Ig strand B [structural motif]
      cd05874
      Location:40 → 134
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:356 → 444
      Ig; Immunoglobulin domain

    41. XM_063262271.1 → XP_063118341.1  neuronal cell adhesion molecule isoform X31

    42. XM_039112704.2 → XP_038968632.1  neuronal cell adhesion molecule isoform X33

      UniProtKB/TrEMBL
      A6HBE7, D4A8C2, Q6PW38
      Conserved Domains (6) summary
      cd00063
      Location:631 → 721
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:937 → 1021
      fn3; Fibronectin type III domain
      pfam13882
      Location:1073 → 1158
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:372 → 376
      Ig; Ig strand B [structural motif]
      cd05874
      Location:40 → 134
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:356 → 444
      Ig; Immunoglobulin domain

    43. XM_063262284.1 → XP_063118354.1  neuronal cell adhesion molecule isoform X43

    44. XM_039112706.2 → XP_038968634.1  neuronal cell adhesion molecule isoform X35

      UniProtKB/TrEMBL
      Q6PW35
      Conserved Domains (6) summary
      cd00063
      Location:631 → 721
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:937 → 1021
      fn3; Fibronectin type III domain
      pfam13882
      Location:1070 → 1155
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:372 → 376
      Ig; Ig strand B [structural motif]
      cd05874
      Location:40 → 134
      IgI_NrCAM; Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:356 → 444
      Ig; Immunoglobulin domain

    45. XM_063262278.1 → XP_063118348.1  neuronal cell adhesion molecule isoform X39

    46. XM_063262279.1 → XP_063118349.1  neuronal cell adhesion molecule isoform X40

    47. XM_063262281.1 → XP_063118351.1  neuronal cell adhesion molecule isoform X41

    48. XM_063262282.1 → XP_063118352.1  neuronal cell adhesion molecule isoform X42

    RNA

    1. XR_001838198.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97686.2 GenPept UniProtKB/Swiss-Prot:P97686

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