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    Necap2 NECAP endocytosis associated 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298598, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Necap2provided by RGD
    Official Full Name
    NECAP endocytosis associated 2provided by RGD
    Primary source
    RGD:735063
    See related
    EnsemblRapid:ENSRNOG00000008427 AllianceGenome:RGD:735063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in endocytosis. Predicted to be located in clathrin-coated pit. Predicted to be part of clathrin vesicle coat. Orthologous to human NECAP2 (NECAP endocytosis associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 168.8), Thymus (RPKM 153.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Necap2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158653347..158665761, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153370338..153382753, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159589856..159602260, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ATPase cation transporting 13A2 Neighboring gene microfibril associated protein 2 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene uncharacterized LOC120103023 Neighboring gene migration and invasion enhancer 1, pseudogene 1 Neighboring gene ribosomal protein S21, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. Ritter B, et al. EMBO Rep, 2003 Nov. PMID 14555962, Free PMC Article
    2. Identification and analysis of plasticity-induced late-response genes. Hong SJ, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14766980, Free PMC Article
    3. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, et al. EMBO J, 2007 Sep 19. PMID 17762867, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72598

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adaptin ear-binding coat-associated protein 2
    Names
    NECAP-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399087.1 → NP_001386016.1  adaptin ear-binding coat-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8L2UIC7
      Related
      ENSRNOP00000011394.5, ENSRNOT00000011394.7

    2. NM_001399088.1 → NP_001386017.1  adaptin ear-binding coat-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6P756
      UniProtKB/TrEMBL
      A6ITR0
      Related
      ENSRNOP00000085569.2, ENSRNOT00000108752.2
      Conserved Domains (1) summary
      pfam07933
      Location:6 → 162
      DUF1681; Protein of unknown function (DUF1681)

    3. NM_001399089.1 → NP_001386018.1  adaptin ear-binding coat-associated protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    4. NM_001399090.1 → NP_001386019.1  adaptin ear-binding coat-associated protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000095787.2, ENSRNOT00000100304.2

    5. NM_199096.2 → NP_954527.2  adaptin ear-binding coat-associated protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RNA

    1. NR_174157.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NR_174158.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NR_174159.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158653347..158665761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287473.1 → XP_063143543.1  adaptin ear-binding coat-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1Y0

    2. XM_006239180.5 → XP_006239242.1  adaptin ear-binding coat-associated protein 2 isoform X1

      Related
      ENSRNOP00000103891.1, ENSRNOT00000142048.1
      Conserved Domains (1) summary
      pfam07933
      Location:6 → 162
      DUF1681; Protein of unknown function (DUF1681)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P756.2 GenPept UniProtKB/Swiss-Prot:Q6P756

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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