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    Pqbp1 polyglutamine binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302557, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pqbp1provided by RGD
    Official Full Name
    polyglutamine binding protein 1provided by RGD
    Primary source
    RGD:1549750
    See related
    EnsemblRapid:ENSRNOG00000007766 AllianceGenome:RGD:1549750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTPase binding activity. Involved in positive regulation of non-motile cilium assembly. Located in centrosome and ciliary base. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 256.0), Thymus (RPKM 206.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pqbp1 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17275445..17280018)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14603516..14608091)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15448570..15453130)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 7 Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Yoh SM, et al. Cell, 2015 Jun 4. PMID 26046437, Free PMC Article
    2. PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Wang Q, et al. Genes Dev, 2013 Mar 15. PMID 23512658, Free PMC Article
    3. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Ikeuchi Y, et al. Cell Rep, 2013 Sep 12. PMID 23994472, Free PMC Article
    4. The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. Kunde SA, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933836
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to exogenous dsRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of defense response to virus by host ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyglutamine-binding protein 1
    Names
    PQBP-1
    polyglutamine tract-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013957.3 → NP_001013979.2  polyglutamine-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Related
      ENSRNOP00000010536.3, ENSRNOT00000010536.7
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    2. NM_001434005.1 → NP_001420934.1  polyglutamine-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    3. NM_001434006.1 → NP_001420935.1  polyglutamine-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    4. NM_001434007.1 → NP_001420936.1  polyglutamine-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17275445..17280018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256708.5 → XP_006256770.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    2. XM_006256707.4 → XP_006256769.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    3. XM_063279921.1 → XP_063135991.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KP66, G3V705

    4. XM_017601995.3 → XP_017457484.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    5. XM_063279922.1 → XP_063135992.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KP66, G3V705

    6. XM_017601996.3 → XP_017457485.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    7. XM_039099631.2 → XP_038955559.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    8. XM_017601994.3 → XP_017457483.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6PCT5
      UniProtKB/TrEMBL
      A6KP66, G3V705
      Conserved Domains (1) summary
      smart00456
      Location:47 → 78
      WW; Domain with 2 conserved Trp (W) residues

    9. XM_063279920.1 → XP_063135990.1  polyglutamine-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KP66, G3V705
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCT5.1 GenPept UniProtKB/Swiss-Prot:Q6PCT5

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