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    Mon1a MON1 homolog A, secretory trafficking associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315999, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mon1aprovided by RGD
    Official Full Name
    MON1 homolog A, secretory trafficking associatedprovided by RGD
    Primary source
    RGD:1308823
    See related
    EnsemblRapid:ENSRNOG00000018502 AllianceGenome:RGD:1308823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308823
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein secretion. Predicted to act upstream of or within establishment of localization in cell; intracellular iron ion homeostasis; and protein transport. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 64.6), Heart (RPKM 56.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mon1a in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117452868..117471780)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108574272..108593163)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116657345..116682172)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 36 Neighboring gene PCNA-associated factor-like Neighboring gene macrophage stimulating 1 receptor Neighboring gene uncharacterized LOC134480232 Neighboring gene actin-like 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. Wang F, et al. Nat Genet, 2007 Aug. PMID 17632513
    2. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux. Vaites LP, et al. Mol Cell Biol, 2018 Jan 1. PMID 29038162, Free PMC Article
    3. BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor. Gerondopoulos A, et al. Curr Biol, 2012 Nov 20. PMID 23084991, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar fusion protein MON1 homolog A
    Names
    MON1 secretory trafficking family member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126284.2 → NP_001119756.2  vacuolar fusion protein MON1 homolog A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I314, B1WC06
      Conserved Domains (1) summary
      pfam03164
      Location:154 → 554
      Mon1; Trafficking protein Mon1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117452868..117471780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081597.2 → XP_038937525.1  vacuolar fusion protein MON1 homolog A isoform X1

      UniProtKB/TrEMBL
      A6I314, B1WC06
      Related
      ENSRNOP00000024966.4, ENSRNOT00000024966.9
      Conserved Domains (1) summary
      pfam03164
      Location:154 → 554
      Mon1; Trafficking protein Mon1

    RNA

    1. XR_010053983.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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