Ptrhd1 peptidyl-tRNA hydrolase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptrhd1provided by RGD
Official Full Name: peptidyl-tRNA hydrolase domain containing 1provided by RGD
Primary source: RGD:1561792
See related: EnsemblRapid:ENSRNOG00000004059 AllianceGenome:RGD:1561792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561792
Summary: Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be located in mitochondrion. Orthologous to human PTRHD1 (peptidyl-tRNA hydrolase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 56.6), Spleen (RPKM 33.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (32937904..32941287)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (27218417..27221805)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (28663602..28666987)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminoacyl-tRNA hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: putative peptidyl-tRNA hydrolase PTRHD1

NP_001127996.1

EC 3.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134524.1 → NP_001127996.1 putative peptidyl-tRNA hydrolase PTRHD1

See identical proteins and their annotated locations for NP_001127996.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HAH5, D3ZBG6

Related

ENSRNOP00000005402.3, ENSRNOT00000005402.6

Conserved Domains (1) summary

cl19212
Location:25 → 139

PTH2_family; Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in ...