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    Cenpx centromere protein X [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688314, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cenpxprovided by RGD
    Official Full Name
    centromere protein Xprovided by RGD
    Primary source
    RGD:1590057
    See related
    EnsemblRapid:ENSRNOG00000090204 AllianceGenome:RGD:1590057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stra13
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in interstrand cross-link repair; replication fork processing; and resolution of meiotic recombination intermediates. Predicted to be located in chromatin. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. Orthologous to human CENPX (centromere protein X). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 76.6), Brain (RPKM 50.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cenpx in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106489796..106492637, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105991469..105994310, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109890904..109893804, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NOTUM, palmitoleoyl-protein carboxylesterase Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene 60S ribosomal protein L36a-like Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Singh TR, et al. Mol Cell, 2010 Mar 26. PMID 20347429, Free PMC Article
    2. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Yan Z, et al. Mol Cell, 2010 Mar 26. PMID 20347428, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of meiotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein X
    Names
    stimulated by retinoic acid 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398950.1 → NP_001385879.1  centromere protein X isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HLI2
      Related
      ENSRNOP00000106628.1, ENSRNOT00000136012.1
      Conserved Domains (1) summary
      pfam09415
      Location:9 → 77
      CENP-X; CENP-S associating Centromere protein X

    2. NM_001398953.1 → NP_001385882.1  centromere protein X isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HLI3
      Related
      ENSRNOP00000104041.1, ENSRNOT00000171484.1
      Conserved Domains (1) summary
      pfam09415
      Location:9 → 106
      CENP-X; CENP-S associating Centromere protein X

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106489796..106492637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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