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    Akt1s1 AKT1 substrate 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292887, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Akt1s1provided by RGD
    Official Full Name
    AKT1 substrate 1provided by RGD
    Primary source
    RGD:1312049
    See related
    EnsemblRapid:ENSRNOG00000020289 AllianceGenome:RGD:1312049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PRAS40
    Summary
    Predicted to enable protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TORC1 signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Part of protein-containing complex. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 103.8), Heart (RPKM 95.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akt1s1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104469823..104476168)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95333186..95339678)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100845443..100851961)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene activating transcription factor 5 Neighboring gene nucleoporin 62 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene polynucleotide kinase 3'-phosphatase Neighboring gene PTOV1, extended AT-hook containing adaptor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes. Hao J, et al. J Cell Physiol, 2014 Aug. PMID 24347388
    2. PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy. Dey N, et al. J Cell Physiol, 2010 Oct. PMID 20629086, Free PMC Article
    3. Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Nascimento EB, et al. Diabetes, 2006 Dec. PMID 17130464
    4. Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Saito A, et al. Stroke, 2006 Feb. PMID 16397181
    5. PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. Xiong X, et al. Neurobiol Dis, 2014 Jun. PMID 24583056, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt to mTOR
      Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
    2. These data suggested that phosphorylation of PRAS40-Thr246 mediated abnormal lipid metabolism in kidney of diabetes and might be the potential target for treating lipogenesis of diabetic nephropathy.
      Title: Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes.
    3. Taken together, these data demonstrate that IGF-1 stimulates the phosphorylation of PRAS40 at Thr246 in neuronal cells and the effect of IGF-1 is mediated, at least in part, by the PI3K/Akt signaling pathway.
      Title: Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells.
    4. Data identify high glucose-induced phosphorylation and inactivation of PRAS40 as a central node for mesangial cell hypertrophy in diabetic nephropathy.
      Title: PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy.
    5. effect of in vivo insulin action on phosphorylation of the PKB/Akt substrate 40
      Title: Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.
    6. overexpression of SOD1 in the Tg rats results in an increase in endogenous pPRAS40 and a decrease in motor neuron death through the PI3K/Akt pathway.
      Title: Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline-rich AKT1 substrate 1
    Names
    AKT1 substrate 1 (proline-rich)
    PKB/Akt substrate 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106259.3 → NP_001099729.2  proline-rich AKT1 substrate 1

      See identical proteins and their annotated locations for NP_001099729.2

      Status: VALIDATED

      Source sequence(s)
      BI276211, EV773331, FM032217, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAT2, A6JAT3
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104469823..104476168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759335.4 → XP_008757557.1  proline-rich AKT1 substrate 1 isoform X5

      Conserved Domains (1) summary
      pfam15798
      Location:42 → 166
      PRAS; Proline-rich AKT1 substrate 1

    2. XM_063283983.1 → XP_063140053.1  proline-rich AKT1 substrate 1 isoform X1

      Related
      ENSRNOP00000101438.1, ENSRNOT00000167805.1

    3. XM_006229004.5 → XP_006229066.1  proline-rich AKT1 substrate 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRQ9, A6JAT2
      Related
      ENSRNOP00000079788.1, ENSRNOT00000114815.2
      Conserved Domains (1) summary
      pfam15798
      Location:143 → 267
      PRAS; Proline-rich AKT1 substrate 1

    4. XM_006229005.5 → XP_006229067.1  proline-rich AKT1 substrate 1 isoform X3

      UniProtKB/TrEMBL
      A6JAT2
      Conserved Domains (1) summary
      pfam15798
      Location:135 → 259
      PRAS; Proline-rich AKT1 substrate 1

    5. XM_039104846.2 → XP_038960774.1  proline-rich AKT1 substrate 1 isoform X4

      UniProtKB/TrEMBL
      A6JAT2, A6JAT3
      Conserved Domains (1) summary
      pfam15798
      Location:128 → 252
      PRAS; Proline-rich AKT1 substrate 1
    Nucleotide Protein Strain
    Heading Accession and Version

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