Hoga1 4-hydroxy-2-oxoglutarate aldolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hoga1provided by RGD
Official Full Name: 4-hydroxy-2-oxoglutarate aldolase 1provided by RGD
Primary source: RGD:1310475
See related: EnsemblRapid:ENSRNOG00000029501 AllianceGenome:RGD:1310475
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Npl2; Dhdpsl; RGD1310475
Summary: Predicted to enable (R,S)-4-hydroxy-2-oxoglutarate aldolase activity; N-acetylneuraminate lyase activity; and protein homodimerization activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 3. Orthologous to human HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 935.6), Liver (RPKM 529.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (250806430..250833544)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (240856991..240884243)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (261291742..261319743)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA849895 (e-PCR)
- UniSTS:261140

RH140725 (e-PCR)
- UniSTS:222791

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity	ISO Inferred from Sequence Orthology more info
enables N-acetylneuraminate lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 4-hydroxyproline catabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glyoxylate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxalate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyruvate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Names: N-acetylneuraminate pyruvate lyase 2 (putative); dihydrodipicolinate synthase-like, mitochondrial; probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

NP_001099825.1

EC 4.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.