Oaz3 ornithine decarboxylase antizyme 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Oaz3provided by RGD
Full Name: ornithine decarboxylase antizyme 3provided by RGD
Primary source: RGD:1599278
See related: EnsemblRapid:ENSRNOG00000020863 AllianceGenome:RGD:1599278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Az3; Oaz-t; ODC-Az 3
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) codon that is highly conserved among the antizyme 3 orthologs. [provided by RefSeq, Dec 2014]
Expression: Restricted expression toward (RPKM 4931.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (184762242..184765176, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182073212..182076147, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (195675925..195678859, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity.
Title: Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity.
N-terminal protein sequencing suggests translation initiation from a non-AUG (CUG) start site.
Title: Mammalian transcription in support of hybrid mRNA and protein synthesis in testis and lung.

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General gene information

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Markers

Oaz3 (e-PCR), detects polymorphism
- UniSTS:531480

UniSTS:492264 (e-PCR)
- UniSTS:492264

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ankyrin repeat binding	IDA Inferred from Direct Assay more info	PubMed
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of polyamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of polyamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ornithine decarboxylase antizyme 3

Names: antizyme 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.