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    Btk Bruton tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367901, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Btkprovided by RGD
    Official Full Name
    Bruton tyrosine kinaseprovided by RGD
    Primary source
    RGD:1359683
    See related
    EnsemblRapid:ENSRNOG00000052407 AllianceGenome:RGD:1359683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein tyrosine kinase activity. Involved in several processes, including positive regulation of gene expression; positive regulation of hypersensitivity; and regulation of B cell activation. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 217.2), Thymus (RPKM 46.2) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btk in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102016070..102055448, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97722796..97762315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105360922..105390580, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) 1 Neighboring gene translocase of inner mitochondrial membrane 8A1 Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Roschewski M, et al. Sci Immunol, 2020 Jun 5. PMID 32503877, Free PMC Article
    2. Purification of a major tyrosine kinase from RBL-2H3 cells phosphorylating Fc epsilon RI gamma-cytoplasmic domain and identification as the Btk tyrosine kinase. Price DJ, et al. Biochim Biophys Acta, 1995 Mar 16. PMID 7696342
    3. Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages. Shahan TA, et al. J Biol Chem, 2000 Apr 7. PMID 10744701
    4. Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit Fc epsilon RI signaling in the RBL-2H3 cell line. Dauvillier S, et al. J Immunol, 2002 Sep 1. PMID 12193692
    5. Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA). Heinonen JE, et al. FEBS Lett, 2002 Sep 11. PMID 12220673

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
      Title: Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
    2. Btk together with PI3-kinase are part of TLR2 multiprotein complex and mediate LTA-induced TLR2 responses in macrophages.
      Title: Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell affinity maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interleukin-7 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to molecule of fungal origin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eosinophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of leukocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-17A production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synoviocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type I hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type III hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase BTK
    Names
    Bruton agammaglobulinemia tyrosine kinase
    NP_001007799.2
    XP_038955880.1
    XP_038955881.1
    XP_038955882.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007798.2 → NP_001007799.2  tyrosine-protein kinase BTK

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K6M9, Q5S255
      Related
      ENSRNOP00000073875.2, ENSRNOT00000086863.3
      Conserved Domains (4) summary
      cd05113
      Location:399 → 654
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:276 → 380
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:219 → 273
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:6 → 168
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      102016070..102055448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099954.2 → XP_038955882.1  tyrosine-protein kinase BTK isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6M9, Q5S255
      Conserved Domains (4) summary
      cd05113
      Location:399 → 654
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:276 → 380
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:219 → 273
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:6 → 168
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

    2. XM_039099952.2 → XP_038955880.1  tyrosine-protein kinase BTK isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6M9, Q5S255
      Conserved Domains (4) summary
      cd05113
      Location:399 → 654
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:276 → 380
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:219 → 273
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:6 → 168
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

    3. XM_039099953.2 → XP_038955881.1  tyrosine-protein kinase BTK isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6M9, Q5S255
      Conserved Domains (4) summary
      cd05113
      Location:399 → 654
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:276 → 380
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:219 → 273
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:6 → 168
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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