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    Aspn asporin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306805, updated on 2-Nov-2024

    Summary

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    Symbol
    Aspnprovided by RGD
    Full Name
    asporinprovided by RGD
    Primary source
    RGD:1549776
    See related
    EnsemblRapid:ENSRNOG00000015410 AllianceGenome:RGD:1549776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aspnl1
    Summary
    Predicted to enable calcium ion binding activity. Involved in response to fluoride. Located in cell projection. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: GeneIDs 103690027 and 306805 are annotated independently on Rnor_6.0 but may be redundant loci. [06 Feb 2015]
    Expression
    Biased expression in Heart (RPKM 139.2), Muscle (RPKM 96.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aspn in Genome Data Viewer
    Location:
    17p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15286338..15310567, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15079910..15104369, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (14655958..14681355, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteoglycin Neighboring gene osteomodulin Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene ribosomal protein L6, pseudogene 6 Neighboring gene extracellular matrix protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of PLAP-1 in bone marrow stromal cells inhibits the rat critical-size skull defect repair. Yu X, et al. J Mol Histol, 2015 Jun. PMID 26031659
    2. Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells. Sun J, et al. J Mol Histol, 2014 Oct. PMID 25038933
    3. Asporin and the mineralization process in fluoride-treated rats. Houari S, et al. J Bone Miner Res, 2014 Jun. PMID 24967458
    4. Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Rodriguez-Lopez J, et al. Arthritis Res Ther, 2006. PMID 16542493, Free PMC Article
    5. Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Shi D, et al. Arthritis Res Ther, 2011 Feb 17. PMID 21329514, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of PLAP-1 in rat bone marrow stromal cells inhibits new bone formation and mineralization in rat critical-size skull defects in vivo.
      Title: Overexpression of PLAP-1 in bone marrow stromal cells inhibits the rat critical-size skull defect repair.
    2. Data suggest that transfected periodontal ligament-associated protein-1 (PLAP-1, asporin) has an inhibitory function in bone marrow stromal cells (rBMSCs) when they differentiate into osteoblast-like cells.
      Title: Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells.
    3. A model is proposed that predicts impaired mineral formation associated with the deficiency and excess of asporin.
      Title: Asporin and the mineralization process in fluoride-treated rats.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tooth mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to fluoride IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    asporin
    Names
    asporin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014008.2 → NP_001014030.1  asporin precursor

      See identical proteins and their annotated locations for NP_001014030.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J6W0, F7F5B0, M0R5F1, Q5XIH1
      Related
      ENSRNOP00000020704.4, ENSRNOT00000020704.7
      Conserved Domains (4) summary
      smart00013
      Location:70 → 99
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:141 → 347
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:79 → 98
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 157
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15286338..15310567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253695.5 → XP_006253757.1  asporin isoform X1

      See identical proteins and their annotated locations for XP_006253757.1

      UniProtKB/TrEMBL
      A6J6W0, F7F5B0, M0R5F1, Q5XIH1
      Conserved Domains (4) summary
      smart00013
      Location:70 → 99
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:141 → 347
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:79 → 98
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 157
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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