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    Rbm5 RNA binding motif protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300996, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rbm5provided by RGD
    Official Full Name
    RNA binding motif protein 5provided by RGD
    Primary source
    RGD:1305059
    See related
    EnsemblRapid:ENSRNOG00000018153 AllianceGenome:RGD:1305059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 483.9), Spleen (RPKM 372.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm5 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117298866..117328107, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108420220..108449481, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116502941..116532178, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480231 Neighboring gene G protein subunit alpha transducin 1 Neighboring gene semaphorin 3F Neighboring gene RNA binding motif protein 6 Neighboring gene cofilin 1 like 1 Neighboring gene enolase 1, pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis. Zhang J, et al. Int J Biochem Cell Biol, 2015 Mar. PMID 25578565
    2. Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons. Jackson TC, et al. Neuroscience, 2017 Oct 11. PMID 28818525, Free PMC Article
    3. Differential downregulation of Rbm5 and Rbm10 during skeletal and cardiac differentiation. Loiselle JJ, et al. In Vitro Cell Dev Biol Anim, 2014 Apr. PMID 24178303
    4. Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. Fushimi K, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18840686, Free PMC Article
    5. Death by splicing: tumor suppressor RBM5 freezes splice-site pairing. Kotlajich MV, et al. Mol Cell, 2008 Oct 24. PMID 18951082

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RBM5 regulates Rab4a in rat neurons
      Title: Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons.
    2. findings indicate that RBM5 promotes neuronal apoptosis through modulating p53 signaling pathway following SCI.
      Title: RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis.
    3. This work establishes myoblast differentiation as a relevant model in which to conduct functional studies regarding Rbm5 and Rbm10.
      Title: Differential downregulation of Rbm5 and Rbm10 during skeletal and cardiac differentiation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100548.2 → NP_001094018.1  RNA-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001094018.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      B2GV05
      UniProtKB/TrEMBL
      A0A8L2R731
      Related
      ENSRNOP00000024529.7, ENSRNOT00000024529.8
      Conserved Domains (6) summary
      sd00025
      Location:185 → 204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd16168
      Location:455 → 510
      OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
      pfam00641
      Location:181 → 210
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam01585
      Location:743 → 787
      G-patch; G-patch domain
      cd12752
      Location:93 → 179
      RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)
      cd12755
      Location:229 → 314
      RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)

    2. NM_001433315.1 → NP_001420244.1  RNA-binding protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      B2GV05

    3. NM_001433316.1 → NP_001420245.1  RNA-binding protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      B2GV05

    4. NM_001433317.1 → NP_001420246.1  RNA-binding protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117298866..117328107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243739.5 → XP_006243801.1  RNA-binding protein 5 isoform X1

      Conserved Domains (6) summary
      sd00025
      Location:185 → 204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd16168
      Location:455 → 510
      OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
      pfam00641
      Location:181 → 210
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam01585
      Location:743 → 787
      G-patch; G-patch domain
      cd12752
      Location:93 → 179
      RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)
      cd12755
      Location:229 → 314
      RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)

    2. XM_006243738.5 → XP_006243800.1  RNA-binding protein 5 isoform X1

      Conserved Domains (6) summary
      sd00025
      Location:185 → 204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd16168
      Location:455 → 510
      OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
      pfam00641
      Location:181 → 210
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam01585
      Location:743 → 787
      G-patch; G-patch domain
      cd12752
      Location:93 → 179
      RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)
      cd12755
      Location:229 → 314
      RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)

    3. XM_039081222.2 → XP_038937150.1  RNA-binding protein 5 isoform X1

      UniProtKB/Swiss-Prot
      B2GV05
      UniProtKB/TrEMBL
      A0A8L2R731
      Conserved Domains (6) summary
      sd00025
      Location:185 → 204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd16168
      Location:455 → 510
      OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
      pfam00641
      Location:181 → 210
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam01585
      Location:743 → 787
      G-patch; G-patch domain
      cd12752
      Location:93 → 179
      RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)
      cd12755
      Location:229 → 314
      RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)

    4. XM_039081223.2 → XP_038937151.1  RNA-binding protein 5 isoform X2

      Conserved Domains (5) summary
      sd00025
      Location:13 → 32
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd16168
      Location:283 → 338
      OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
      pfam00641
      Location:9 → 38
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam01585
      Location:571 → 615
      G-patch; G-patch domain
      cd12755
      Location:57 → 142
      RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)

    5. XM_063265245.1 → XP_063121315.1  RNA-binding protein 5 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GV05.1 GenPept UniProtKB/Swiss-Prot:B2GV05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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