Fxyd4 FXYD domain-containing ion transport regulator 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fxyd4provided by RGD
Official Full Name: FXYD domain-containing ion transport regulator 4provided by RGD
Primary source: RGD:70998
See related: EnsemblRapid:ENSRNOG00000014578 AllianceGenome:RGD:70998
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chif
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Kidney (RPKM 102.7), Uterus (RPKM 19.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (152782181..152786118, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (151109779..151113659, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (149984206..149988744, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid bilayer membrane
Title: Structures of the FXYD regulatory proteins in lipid micelles and membranes.
CHIF drastically modulates the KCNQ1 current; in the presence of CHIF, the KCNQ1 channels open at all membrane potentials.
Title: The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
Data describe the interactions of rat FXYD1,-2, and -4 proteins with rat alpha1 subunits of Na(+),K(+)-ATPase.
Title: Structural interactions between FXYD proteins and Na+,K+-ATPase: alpha/beta/FXYD subunit stoichiometry and cross-linking.
molecular cloning, protein expression, sequencing and NMR structure determination
Title: Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers.
the unchanged levels of FXYD2 and FXYD4 proteins suggest that they are not primary determinants for urine electrolyte composition during NaCl depletion
Title: Locations, abundances, and possible functions of FXYD ion transport regulators in rat renal medulla.
study provides the first systematic analysis of structure-function relations of corticosteroid hormone-induced factor and Na,K-ATPase gamma subunit gamma
Title: Structure-function relations of interactions between Na,K-ATPase, the gamma subunit, and corticosteroid hormone-induced factor.
show that the helical regions and connecting segments of FXYD1, FXYD3, and FXYD4 determined in micelles by NMR spectroscopy coincide with the positions of intron-exon junctions in the genes
Title: Correlation of gene and protein structures in the FXYD family proteins.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inorganic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: FXYD domain-containing ion transport regulator 4

Names: channel-inducing factor; corticosteroid-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368663.1 → NP_001355592.1 FXYD domain-containing ion transport regulator 4 precursor

Status: REVIEWED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q63113

UniProtKB/TrEMBL

A6IL54

Conserved Domains (1) summary

cd20322
Location:21 → 67

FXYD4; FXYD domain-containing ion transport regulator 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

152782181..152786118 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108308.2 → XP_038964236.1 FXYD domain-containing ion transport regulator 4 isoform X1

UniProtKB/Swiss-Prot

Q63113

UniProtKB/TrEMBL

A6IL54

Conserved Domains (1) summary

cd20322
Location:21 → 67

FXYD4; FXYD domain-containing ion transport regulator 4
XM_063286657.1 → XP_063142727.1 FXYD domain-containing ion transport regulator 4 isoform X1

UniProtKB/Swiss-Prot

Q63113

UniProtKB/TrEMBL

A6IL54

Related

ENSRNOP00000104679.1, ENSRNOT00000158850.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_022388.1: Suppressed sequence

Description

NM_022388.1: This RefSeq was removed because currently there is insufficient support for the transcript.