Nacc1 nucleus accumbens associated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nacc1provided by RGD
Official Full Name: nucleus accumbens associated 1provided by RGD
Primary source: RGD:621003
See related: EnsemblRapid:ENSRNOG00000002864 AllianceGenome:RGD:621003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nac1; Nac-1; Btbd14b
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Orthologous to human NACC1 (nucleus accumbens associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 111.1), Kidney (RPKM 77.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40373436..40391351)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23468688..23486528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25783686..25801526, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

aberrantly regulated NAC1 expression in the mammalian brain may contribute to programmed cell death
Title: NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells.
The two isoforms of NAC-1 may differentially affect neuronal functions, including the regulation of cocaine-induced locomotion. The longer isoform was the more abundant of the two NAC1 proteins and the ratio between them differed throughout the rat brain.
Title: Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleus accumbens-associated protein 1

Names: BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; nucleus accumbens-1; transcriptional repressor NAC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134413.2 → NP_599240.1 nucleus accumbens-associated protein 1

See identical proteins and their annotated locations for NP_599240.1

Status: PROVISIONAL

Source sequence(s)

AF015911

UniProtKB/Swiss-Prot

O35260

UniProtKB/TrEMBL

A6IY85

Conserved Domains (2) summary

smart01025
Location:382 → 460

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40373436..40391351

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277753.1 → XP_063133823.1 nucleus accumbens-associated protein 1 isoform X3

Related

ENSRNOP00000108418.1, ENSRNOT00000173116.1
XM_008772346.4 → XP_008770568.1 nucleus accumbens-associated protein 1 isoform X2

See identical proteins and their annotated locations for XP_008770568.1

UniProtKB/Swiss-Prot

O35260

UniProtKB/TrEMBL

A6IY85

Related

ENSRNOP00000071927.3, ENSRNOT00000091670.3

Conserved Domains (2) summary

smart01025
Location:382 → 460

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
XM_006255214.5 → XP_006255276.1 nucleus accumbens-associated protein 1 isoform X1

Conserved Domains (3) summary

smart00225
Location:57 → 148

BTB; Broad-Complex, Tramtrack and Bric a brac

smart01025
Location:408 → 486

BEN; The BEN domain is found in diverse animal proteins

pfam00651
Location:46 → 147

BTB; BTB/POZ domain