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    Tomm5 translocase of outer mitochondrial membrane 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680080, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tomm5provided by RGD
    Official Full Name
    translocase of outer mitochondrial membrane 5provided by RGD
    Primary source
    RGD:1596808
    See related
    AllianceGenome:RGD:1596808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein targeting to mitochondrion and protein transport. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM5 (translocase of outer mitochondrial membrane 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 451.8), Muscle (RPKM 325.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tomm5 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64158026..64160857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59362360..59365191, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60655708..60658568, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit E Neighboring gene F-box protein 10 Neighboring gene ribosomal protein L24-like Neighboring gene uncharacterized LOC120103148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, et al. Biol Chem, 2015 Nov. PMID 25980382
    2. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Kato H, et al. Biochem Biophys Res Commun, 2008 May 9. PMID 18331822
    3. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, et al. Biochim Biophys Acta, 2015 May. PMID 25633533
    4. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    5. Unlocking the presequence import pathway. Schulz C, et al. Trends Cell Biol, 2015 May. PMID 25542066

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial outer membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM5 homolog
    Names
    translocase of outer mitochondrial membrane 5 homolog
    translocase of outer mitochondrial membrane 5 homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398960.1 → NP_001385889.1  mitochondrial import receptor subunit TOM5 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IJ86
      Conserved Domains (1) summary
      pfam10642
      Location:1 → 50
      Tom5; Mitochondrial import receptor subunit or translocase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      64158026..64160857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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